2,3-dimethoxynaphthalene

反応条件: temp:120.01; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: This product was prepared from 2,3-dimethoxynaphthalene (3.76 g), aluminium chloride (2.93 g) and 4-chlorobutanoylchloride (2.96 g) in methylene chloride (100 ml) as described in example 9(a) above.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: This product was prepared from 2,3-dimethoxynaphthalene (3.76 g), aluminium chloride (2.93 g) and 4-chlorobutanoylchloride (2.96 g) in methylene chloride (100 ml) as described in example 9(a) above.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Aluminium chloride (9.5 g) was added to a solution of 2,3-dimethoxynaphthalene (10 g) and succinic anhydride 7.1 g in methylene chloride (140 ml). The mixture was stirred at room temperature overnight and then treated with water and filtered. The resulting solid was taken into 1 M sodium hydroxide, washed once with methylene chloride, acidified and filtered. Yield: 8.3 g, melting point 215-229° C. filtered washed once with methylene chloride filtered

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Aluminium chloride (9.5 g) was added to a solution of 2,3-dimethoxynaphthalene (10 g) and succinic anhydride 7.1 g in methylene chloride (140 ml). The mixture was stirred at room temperature overnight and then treated with water and filtered. The resulting solid was taken into 1 M sodium hydroxide, washed once with methylene chloride, acidified and filtered. Yield: 8.3 g, melting point 215-229° C. filtered washed once with methylene chloride filtered

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: n-Butyl lithium in hexane (1.6 N, 31.3 ml) was gradually added to a solution of 2,3-dimethoxynaphthalene (9.4 g) and N,N,N′,N′-tetramethylethylenediamine (7.4 ml) in ether (150 ml) under argon at 0° C. The reaction mixture was stirred at room temperature for two hours, cooled to 0° C. and DMF (7.3 g) in ether (20 ml) added. The reaction mixture was stirred at room temperature overnight and poured in ice water. The product was extracted with ether, washed with water, dried, evaporated and recrystallized from ether. Yield: 4.2 g. cooled to 0° C. The reaction mixture was stirred at room temperature overnight The product was extracted with ether washed with water dried evaporated recrystallized from ether

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Aluminium chloride (2.66 g) was added to a solution of: heptanoylchloride (3.1 ml) and 2,3-dimethoxynaphthalene (3.76 g) in methylene chloride (50 ml) at 0° C. The reaction mixture was stirred at room temperature overnight and then worked up as described in example 3(a). The crude product was recrystallized from ethanol. Yield: 2.8 g, melting point 77-78° C. The crude product was recrystallized from ethanol

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Aluminium chloride (2.66 g) was added to a solution of: heptanoylchloride (3.1 ml) and 2,3-dimethoxynaphthalene (3.76 g) in methylene chloride (50 ml) at 0° C. The reaction mixture was stirred at room temperature overnight and then worked up as described in example 3(a). The crude product was recrystallized from ethanol. Yield: 2.8 g, melting point 77-78° C. The crude product was recrystallized from ethanol

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The solution of 2,3-dimethoxynaphthalene (1.9 g), palmitoyl chloride (3.2 ml) and aluminium chloride (1.5 g) in methylene chloride (40 ml) was stirred at ambient temperature overnight. The reaction mixture was worked up as described in example 4(a). The crude product was recrystallized from ethyl acetate-heptane. Yield 2.0 g. The crude product was recrystallized from ethyl acetate-heptane

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The solution of 2,3-dimethoxynaphthalene (1.9 g), palmitoyl chloride (3.2 ml) and aluminium chloride (1.5 g) in methylene chloride (40 ml) was stirred at ambient temperature overnight. The reaction mixture was worked up as described in example 4(a). The crude product was recrystallized from ethyl acetate-heptane. Yield 2.0 g. The crude product was recrystallized from ethyl acetate-heptane

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The solution of 2,3-dimethoxynaphthalene (16.5 g ), isobutyroylchloride (12.5 g) and aluminum chloride (15.7 g) in methylene chloride (200 ml) was stirred at ambient temperature overnight. The solution was then washed with saturated sodium bicarbonate and water, dried with sodium sulfate and evaporated. Finally the crude product was triturated with ether. Yield: 13.5 g, melting point 103-105° C. The solution was then washed with saturated sodium bicarbonate and water dried with sodium sulfate evaporated Finally the crude product was triturated with ether

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Aluminum chloride (16.0 g) was added to a solution of 2,3-dimethoxynaphthalene (18.0 g) and benzoylchloride (12.0 g) in cold methylene chloride (400 ml) and the solution was stirred overnight. After treatment with cold water the phases were separated and the methylene chloride phase washed with 1 M sodium hydroxide. The product was triturated with warm ether. Yield: 7 g, melting point 124-125° C. After treatment with cold water the phases were separated the methylene chloride phase washed with 1 M sodium hydroxide The product was triturated with warm ether