6-[tert-butyl(dimethyl)silyl]oxyhexan-1-ol

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Using the procedure of Step A of Preparation 16, 8.12 g of sodium hydride at 50% in oil, 20 g of 1,6-hexane diol and 25.5 g of terbutyl dimethyl chloro silane were reacted to obtain after chromatography, 20.7 g of the expected product. were reacted

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Using the procedure of Step A of Preparation 16, 8.12 g of sodium hydride at 50% in oil, 20 g of 1,6-hexane diol and 25.5 g of tertbutyl dimethyl chloro silane were reacted to obtain after chromatography, 20.7 g of the expected product. were reacted

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a solution of 232 mg of alcohol 16b in 10 ml of ether was added 1 ml of triethyl amine, followed at 0° C. by 80 μl of mesyl chloride. The mixture was stirred at ambient temperature for 1 hr and then poured into water and extracted into ether. The organic extract was washed with water, dried and concentrated, to give 320 mg of 16c as a colorless oil. extracted into ether The organic extract was washed with water dried concentrated

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Using the procedure of Step A of Preparation 16, 8.12 g of sodium hydride at 50% in oil, 20 g of 1,6-hexane diol and 25.5 g of terbutyl dimethyl chloro silane were reacted to obtain after chromatography, 20.7 g of the expected product. were reacted

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Using the procedure of Step A of Preparation 16, 8.12 g of sodium hydride at 50% in oil, 20 g of 1,6-hexane diol and 25.5 g of tertbutyl dimethyl chloro silane were reacted to obtain after chromatography, 20.7 g of the expected product. were reacted