ethyl 2-[(2-methylphenyl)methyl]-3-oxobutanoate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 325 g (2.4 moles) of sulfuryl chloride were added dropwise to 511.0 g (2.2 moles) of ethyl 2-(o-methylbenzyl)-acetoacetate in the course of 2 hours, while stirring. Thereafter, the mixture was heated at 50° to 55° C. for 4 hours. The crude product was purified by vacuum distillation without a column. 547 g (92% of the theoretical yield) of ethyl 2-chloro-2-(o-methylbenzyl)-acetoacetate of boiling point 120° C. at 0.01 mm Hg were obtained. Thereafter, the mixture was heated at 50° to 55° C. for 4 hours The crude product was purified by vacuum distillation without a column

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 344 g (2.45 moles) of o-methylbenzyl chloride and 3.5 moles of 25% strength aqueous NaOH solution were added dropwise to a refluxed, thoroughly stirred solution of 455 g (3.5 moles) of ethyl acetoacetate, 35 g (0.11 moles) of tetrabutylammonium bromide and 1.2 liters of toluene in the course of 2 hours, simultaneously from two dropping funnels. Thereafter, stirring was continued for a further 2 hours with refluxing. After the reaction solution had cooled, water was added, the phases were separated and the organic phase was washed once with water, once with dilute phosphoric acid and again with water and was then stirred with solid sodium bicarbonate. The mixture was filtered, the solution was freed from toluene and the residue was subjected to vacuum distillation over a 10 cm Vigreux column. 390 g (68% of the theoretical yield) of ethyl 2-(o-methylbenzyl)-acetoacetate of boiling point 100°-105° C. at 0.01 mm Hg were obtained. with refluxing After the reaction solution had cooled the phases were separated the organic phase was washed once with water, once with dilute phosphoric acid and again with water was then stirred with solid sodium bicarbonate The mixture was filtered the residue was subjected to vacuum distillation over a 10 cm Vigreux column

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 325 g (2.4 moles) of sulfuryl chloride were added dropwise to 511.0 g (2.2 moles) of ethyl 2-(o-methylbenzyl)-acetoacetate in the course of 2 hours, while stirring. Thereafter, the mixture was heated at 50° to 55° C. for 4 hours. The crude product was purified by vacuum distillation without a column. 547 g (92% of the theoretical yield) of ethyl 2-chloro-2-(o-methylbenzyl)-acetoacetate of boiling point 120° C. at 0.01 mm Hg were obtained. Thereafter, the mixture was heated at 50° to 55° C. for 4 hours The crude product was purified by vacuum distillation without a column

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 344 g (2.45 moles) of o-methylbenzyl chloride and 3.5 moles of 25% strength aqueous NaOH solution were added dropwise to a refluxed, thoroughly stirred solution of 455 g (3.5 moles) of ethyl acetoacetate, 35 g (0.11 moles) of tetrabutylammonium bromide and 1.2 liters of toluene in the course of 2 hours, simultaneously from two dropping funnels. Thereafter, stirring was continued for a further 2 hours with refluxing. After the reaction solution had cooled, water was added, the phases were separated and the organic phase was washed once with water, once with dilute phosphoric acid and again with water and was then stirred with solid sodium bicarbonate. The mixture was filtered, the solution was freed from toluene and the residue was subjected to vacuum distillation over a 10 cm Vigreux column. 390 g (68% of the theoretical yield) of ethyl 2-(o-methylbenzyl)-acetoacetate of boiling point 100°-105° C. at 0.01 mm Hg were obtained. with refluxing After the reaction solution had cooled the phases were separated the organic phase was washed once with water, once with dilute phosphoric acid and again with water was then stirred with solid sodium bicarbonate The mixture was filtered the residue was subjected to vacuum distillation over a 10 cm Vigreux column