tert-butyl N-[(2S)-4-hydroxybutan-2-yl]carbamate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The product of example 22 (a) (1.06 g, 5.6 mmol) was dissolved in CH2Cl2 (10 ml) and cooled in an ice bath while stirring under argon. Triethylamine (0.667 g, 6.6 mmol) was added followed by the dropwise addition of methanesulfonyl chloride (0.687 g, 6 mmol). After 10 minutes the ice bath was removed and the mixture stirred at rt for 2 h. The solvent was stripped off and the title compound was isolated as a yellow oil. ES (+) MS m/e=268 (MH+), 290 (MNa+) cooled in an ice bath After 10 minutes the ice bath was removed the mixture stirred at rt for 2 h