2-amino-N,N-diphenylacetamide

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Working in a manner similar to that described in Example 9, but starting with 2-naphthalenecarboxylic acid (0.95 g), oxalyl dichloride (0.7 g), 2-amino-N,N-diphenylacetamide (1.2 g) and triethylamine (0.8 g), and after recrystallization in acetonitrile, N-(diphenylcarbamoylmethyl)-2-naphthalenecarboxamide (1.2 g), m.p. 205° C., is obtained. after recrystallization in acetonitrile

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: N,N,'-Carbonyldiimidazole (0.72 g) is added to a solution of 2-amino-N,N-diphenylacetamide (1 g) in anhydrous tetrahydrofuran (15 cc). The solution is stirred for 2 hours at a temperature in the region of 25° C. and 3-methylthioaniline (1.2 g) is then added. The solution obtained is stirred under reflux for 12 hours and then concentrated to dryness under reduced pressure (2.7 kPa). The residue obtained is taken up with distilled water (60 cc) and stirred for 30 minutes at a temperature in the region of 20° C. The insoluble product is separated by filtration, washed with distilled water and dried in the air. After recrystallization in acetonitrile, 2-[3-(3-methylthiophenyl)ureido]-N,N-diphenylacetamide (1 g), m.p. 182° C., is obtained. is then added The solution obtained under reflux for 12 hours concentrated to dryness under reduced pressure (2.7 kPa) The residue obtained stirred for 30 minutes at a temperature in the region of 20° C The insoluble product is separated by filtration washed with distilled water dried in the air After recrystallization in acetonitrile

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Working in a manner similar to that described in Example 1, but starting with 2-amino-N,N-diphenylacetamide (2 g) and 3-methoxyphenyl isocyanate (1.3 g), and after recrystallization in acetonitrile, 2-[3-(3-methoxyphenyl)ureido]-N,N-diphenylacetamide (2.6 g), m.p. 182° C., is obtained. after recrystallization in acetonitrile

反応条件: temp:25.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 3-Methylphenyl isocyanate (0.59 g) is added at a temperature in the region of 25° C. to a solution of 2-amino-N,N-diphenylacetamide (1 g) in anhydrous tetrahydrofuran (20 cc). The suspension obtained is stirred for 4 hours at a temperature in the region of 25° C. and the insoluble product is separated by filtration. After recrystallization in acetonitrile, N,N-diphenyl-2-[3-(3-methylphenyl)ureido]acetamide (0.8 g), m.p. 240° C., is obtained. The suspension obtained the insoluble product is separated by filtration After recrystallization in acetonitrile