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CCOC(=O)C1CC(CN1)O製品情報
ethyl 4-hydroxypyrrolidine-2-carboxylate (CAS 1079350-28-9) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
想定用途
専門的研究・工業用途限定
データベース ID 423727
安全上の注意
For professional research and industrial use only. Review the supplier safety data sheet before handling.
合成データ
12 反応 · 12 文献
反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-1ea279d2c8d94e32853d193a4bd3b625反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-0b9fbabbf72f448bb78e40f8c7e55ca9反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-1702f4521546472d9de9b1c42b5046ab反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-6d0346860c5b4faaac64e08ef7424db4反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-d34e497cb1bf4636adaebf5868be2330反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-72d517b33a2b44d68990a8d2edb02c18反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-1ea279d2c8d94e32853d193a4bd3b625反応条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 4-Fluoronitrobenzene (0.28 mL, 2.65 mmol), 4-hydroxy-pyrrolidine-2-carboxylic acid ethyl ester (419 mg, 2.65 mmol), and sodium bicarbonate (222 mg, 2.65 mmol) were dissolved in 5 mL dry DMF and heated to 80° C. After 24 h at this temperature, the reaction was cooled and water and ethyl acetate were added. The organic phase washed with brine, dried (MgSO4), and concentrated. Flash chromatography (65-75% ethyl acetate/hexanes) gave 260 mg (35% yield) of the desired product. 1H NMR (CDCl3, 500 MHz) 8.15 (d, J=9.3 Hz, 2H), 6.54 (d, J=9.3 Hz, 2H), 4.60 (m, 1H), 4.41 (d, J=9.2 Hz, 1H), 4.31 (dq, J=10.8, 7.1 Hz, 1H), 4.29 (dq, J=10.8, 7.1 Hz, 1H), 3.73 (dt, J=11.0, 1.2 Hz, 1H), 3.70 (dd, J=11.0, 4.2 Hz, 1H), 2.51 (ddd, J=14.2, 9.2, 4.2 Hz, 1H), 2.35 (dd, J=14.2, 1.2 Hz, 1H), 1.34 (t, J=7.1 Hz, 3H). the reaction was cooled The organic phase washed with brine dried (MgSO4) concentrated
ソース ID: ord-9828116ef54a41858e9aeeeac945cb3a反応条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 4-Fluoronitrobenzene (0.28 mL, 2.65 mmol), 4-hydroxy-pyrrolidine-2-carboxylic acid ethyl ester (419 mg, 2.65 mmol), and sodium bicarbonate (222 mg, 2.65 mmol) were dissolved in 5 mL dry DMF and heated to 80° C. After 24 h at this temperature, the reaction was cooled and water and ethyl acetate were added. The organic phase washed with brine, dried (MgSO4), and concentrated. Flash chromatography (65-75% ethyl acetate/hexanes) gave 260 mg (35% yield) of the desired product. 1H NMR (CDCl3, 500 MHz) 8.15 (d, J=9.3 Hz, 2H), 6.54 (d, J=9.3 Hz, 2H), 4.60 (m, 1H), 4.41 (d, J=9.2 Hz, 1H), 4.31 (dq, J=10.8, 7.1 Hz, 1H), 4.29 (dq, J=10.8, 7.1 Hz, 1H), 3.73 (dt, J=11.0, 1.2 Hz, 1H), 3.70 (dd, J=11.0, 4.2 Hz, 1H), 2.51 (ddd, J=14.2, 9.2, 4.2 Hz, 1H), 2.35 (dd, J=14.2, 1.2 Hz, 1H), 1.34 (t, J=7.1 Hz, 3H). the reaction was cooled The organic phase washed with brine dried (MgSO4) concentrated
ソース ID: ord-9828116ef54a41858e9aeeeac945cb3a反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-0b9fbabbf72f448bb78e40f8c7e55ca9反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-d34e497cb1bf4636adaebf5868be2330反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-72d517b33a2b44d68990a8d2edb02c18PubChem References
化合物の公開データベース記録に掲載された情報源です。
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