4-[(2-bromo-4-fluorophenyl)methyl]morpholine

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:81.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Combine 2-bromo-1-bromomethyl-4-fluoro-benzene (4 g, 14.9 mmol), morpholine (2.6 mL, 29.8 mmol), and diisopropylethylamine (5.2 mL, 29.8 mmol) in acetonitrile (10.0 mL). Heat the reaction mixture at 81° C. for 2 h and cool to RT. Remove the solvent under reduced pressure. Dilute with DCM and wash with water and then aqueous saturated sodium chloride. Dry the organics over sodium sulfate. Filter and remove the solvent under reduced pressure to obtain the title compound (3.9 g, 95%). LCMS (ES) m/z 274 [M+1]+. cool to RT Remove the solvent under reduced pressure Dilute with DCM wash with water Dry the organics over sodium sulfate Filter remove the solvent under reduced pressure

反応条件: temp:81.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Combine 2-bromo-1-bromomethyl-4-fluoro-benzene (4 g, 14.9 mmol), morpholine (2.6 mL, 29.8 mmol), and diisopropylethylamine (5.2 mL, 29.8 mmol) in acetonitrile (10.0 mL). Heat the reaction mixture at 81° C. for 2 h and cool to RT. Remove the solvent under reduced pressure. Dilute with DCM and wash with water and then aqueous saturated sodium chloride. Dry the organics over sodium sulfate. Filter and remove the solvent under reduced pressure to obtain the title compound (3.9 g, 95%). LCMS (ES) m/z 274 [M+1]+. cool to RT Remove the solvent under reduced pressure Dilute with DCM wash with water Dry the organics over sodium sulfate Filter remove the solvent under reduced pressure

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:81.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Combine 2-bromo-1-bromomethyl-4-fluoro-benzene (4 g, 14.9 mmol), morpholine (2.6 mL, 29.8 mmol), and diisopropylethylamine (5.2 mL, 29.8 mmol) in acetonitrile (10.0 mL). Heat the reaction mixture at 81° C. for 2 h and cool to RT. Remove the solvent under reduced pressure. Dilute with DCM and wash with water and then aqueous saturated sodium chloride. Dry the organics over sodium sulfate. Filter and remove the solvent under reduced pressure to obtain the title compound (3.9 g, 95%). LCMS (ES) m/z 274 [M+1]+. cool to RT Remove the solvent under reduced pressure Dilute with DCM wash with water Dry the organics over sodium sulfate Filter remove the solvent under reduced pressure