(2R)-3-[(4-methoxyphenyl)methoxy]propane-1,2-diol

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The crude product of (S)-(+)-4-(4-methoxybenzyloxymethyl)-2,2-dimethyl-1,3-dioxolane (4.1 g) was dissolved in methanol (10 mL), added with 1 N hydrochloric acid and stirred at room temperature for one day. The reaction solution was adjusted to pH 6 by addition of saturated aqueous sodium hydrogencarbonate and extracted four times with dichloromethane. The organic layer was dried over anhydrous sodium sulfate, and the solvent was removed. The residue was purified by silica gel column chromatography to obtain (R)-(+)-3-(4-methoxybenzyloxy)-1,2-propanediol (2.4 g, yield: 69%). extracted four times with dichloromethane The organic layer was dried over anhydrous sodium sulfate the solvent was removed The residue was purified by silica gel column chromatography

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The crude product of (S)-(+)-4-(4-methoxybenzyloxymethyl)-2,2-dimethyl-1,3-dioxolane (4.1 g) was dissolved in methanol (10 mL), added with 1 N hydrochloric acid and stirred at room temperature for one day. The reaction solution was adjusted to pH 6 by addition of saturated aqueous sodium hydrogencarbonate and extracted four times with dichloromethane. The organic layer was dried over anhydrous sodium sulfate, and the solvent was removed. The residue was purified by silica gel column chromatography to obtain (R)-(+)-3-(4-methoxybenzyloxy)-1,2-propanediol (2.4 g, yield: 69%). extracted four times with dichloromethane The organic layer was dried over anhydrous sodium sulfate the solvent was removed The residue was purified by silica gel column chromatography

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The crude product of (S)-(+)-4-(4-methoxybenzyloxymethyl)-2,2-dimethyl-1,3-dioxolane (4.1 g) was dissolved in methanol (10 mL) and the solution was added with 1N hydrochloric acid and stirred at room temperature for one day. The solution was adjusted to pH6 by addition of saturated aqueous sodium hydrogen carbonate, and extracted four times with dichloromethane. After the organic layer was dried over anhydrous sodium sulfate, the solvent was removed. The residue was purified by silica gel column chromatography to obtain (R)-(+)-3-(4-methoxybenzyloxy)-1,2-propandiol (2.4 g, 69%). extracted four times with dichloromethane After the organic layer was dried over anhydrous sodium sulfate the solvent was removed The residue was purified by silica gel column chromatography

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The crude product of (S)-(+)-4-(4-methoxybenzyloxymethyl)-2,2-dimethyl-1,3-dioxolane (4.1 g) was dissolved in methanol (10 mL). The solution was added with 1N hydrochloric acid and stirred at room temperature for one day. The solution was adjusted to pH 6 by addition of saturated sodium hydrogen carbonate, and extracted four times with dichloromethane. After the organic layer was dried over anhydrous sodium sulfate, the solvent was removed and the residue was purified by silica gel column chromatography to obtain (R)-(+)-3-(4-methoxybenzyloxy)-1,2-propanediol (2.4 g, 69%). extracted four times with dichloromethane After the organic layer was dried over anhydrous sodium sulfate the solvent was removed the residue was purified by silica gel column chromatography

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The crude product of (S)-(+)-4-(4-methoxybenzyloxymethyl)-2,2-dimethyl-1,3-dioxolane (4.1 g) was dissolved in methanol (10 mL). The solution was added with 1N hydrochloric acid and stirred at room temperature for one day. The solution was adjusted to pH 6 by addition of saturated aqueous sodium hydrogen carbonate, and extracted four times with dichloromethane. After the organic layer was dried over anhydrous sodium sulfate, the solvent was removed and the residue was purified by silica gel column chromatography to obtain (R)-(+)-3-(4-methoxybenzyloxy)-1,2-propanediol (2.4 g, 69%). extracted four times with dichloromethane After the organic layer was dried over anhydrous sodium sulfate the solvent was removed the residue was purified by silica gel column chromatography