octane-1,2-diol

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A homogeneous clear solution is prepared by adding 3 moles of acetone to 1 mole of octene (1,2) oxide at room temperature. After adding 50 grams of 5% aqueous sulfuric acid to the solution, the acetone is evaporated off and the resulting solution is neutralized by adding an aqueous sodium hydroxide. The neutralized solution is extracted with pet ether and the extract dried over anhydrous magnesium sulfate. The pet ether is stripped off and 1,2-octanediol is obtained by distilling under vacuo, b.p. 103°-105°C/0.2 mm. A homogeneous clear solution is prepared the acetone is evaporated off by adding an aqueous sodium hydroxide The neutralized solution is extracted with pet ether the extract dried over anhydrous magnesium sulfate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A homogeneous clear solution is prepared by adding 3 moles of acetone to 1 mole of octene (1,2) oxide at room temperature. After adding 50 grams of 5% aqueous sulfuric acid to the solution, the acetone is evaporated off and the resulting solution is neutralized by adding an aqueous sodium hydroxide. The neutralized solution is extracted with pet ether and the extract dried over anhydrous magnesium sulfate. The pet ether is stripped off and 1,2-octanediol is obtained by distilling under vacuo, b.p. 103°-105°C/0.2 mm. A homogeneous clear solution is prepared the acetone is evaporated off by adding an aqueous sodium hydroxide The neutralized solution is extracted with pet ether the extract dried over anhydrous magnesium sulfate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 314 g (2.80 mol) of 1-octene were reacted with 330 g (7.17 mol) of formic acid and 232 g (3.41 mol) of a 50% strength aqueous H2O2 solution in accordance with Example 4. 575 g of ethanol were employed for the Marlon AS3 acid-catalyzed transesterification, and the main fraction obtained after the workup by distillation was >99.5% pure, virtually odorless 1,2-octanediol. the main fraction obtained after the workup by distillation

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Racemic 2-n-hexyl-2,3-dihydro-thieno[3,4-b][1,4]dioxine was synthesized by transetherification of 3,4-dimethoxythiophene with racemic 1,2-octanediol as described in EXAMPLE 1. It was characterized by GC-MS and 1H-NMR-spectroscopy, and exhibited no optical rotation.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 314 g (2.80 mol) of 1-octene were reacted with 330 g (7.17 mol) of formic acid and 232 g (3.41 mol) of a 50% strength aqueous H2O2 solution in accordance with Example 4. 575 g of ethanol were employed for the Marlon AS3 acid-catalyzed transesterification, and the main fraction obtained after the workup by distillation was >99.5% pure, virtually odorless 1,2-octanediol. the main fraction obtained after the workup by distillation

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Racemic 2-n-hexyl-2,3-dihydro-thieno[3,4-b][1,4]dioxine was synthesized by transetherification of 3,4-dimethoxythiophene with racemic 1,2-octanediol as described in EXAMPLE 1. It was characterized by GC-MS and 1H-NMR-spectroscopy, and exhibited no optical rotation.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Into a 100 ml 3-neck flask provided with condenser, addition funnel, and magnetic stirrer is charged t-butyl-alcohol (20.0 g), 1-octene (4.48 g), water (1.0 g), NaI (0.03 g) and 0.30 g of the Os(CO)12 /MgO supported catalyst prepared in accordance with Example 1. At ambient temperature (26° C.), 2.0 g of a solution of 90% by weight, tertiary butyl hydroperoxide dissolved in t-butyl alcohol is added dropwise over a period of 2 minutes with stirring. After 12 hours from completion of the addition, the reaction mixture is analyzed by GLC and complete conversion of the hydroperoxide is obtained with a selectivity to 1,2-octanediol of 84%. The results are summarized at Table 1. Into a 100 ml 3-neck flask provided with condenser, addition funnel, and magnetic stirrer prepared in accordance with Example 1 is added dropwise over a period of 2 minutes After 12 hours from completion of the addition

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A homogeneous clear solution is prepared by adding 3 moles of acetone to 1 mole of octene (1,2) oxide at room temperature. After adding 50 grams of 5% aqueous sulfuric acid to the solution, the acetone is evaporated off and the resulting solution is neutralized by adding an aqueous sodium hydroxide. The neutralized solution is extracted with pet ether and the extract dried over anhydrous magnesium sulfate. The pet ether is stripped off and 1,2-octanediol is obtained by distilling under vacuo, b.p. 103°-105°C/0.2 mm. A homogeneous clear solution is prepared the acetone is evaporated off by adding an aqueous sodium hydroxide The neutralized solution is extracted with pet ether the extract dried over anhydrous magnesium sulfate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A homogeneous clear solution is prepared by adding 3 moles of acetone to 1 mole of octene (1,2) oxide at room temperature. After adding 50 grams of 5% aqueous sulfuric acid to the solution, the acetone is evaporated off and the resulting solution is neutralized by adding an aqueous sodium hydroxide. The neutralized solution is extracted with pet ether and the extract dried over anhydrous magnesium sulfate. The pet ether is stripped off and 1,2-octanediol is obtained by distilling under vacuo, b.p. 103°-105°C/0.2 mm. A homogeneous clear solution is prepared the acetone is evaporated off by adding an aqueous sodium hydroxide The neutralized solution is extracted with pet ether the extract dried over anhydrous magnesium sulfate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 314 g (2.80 mol) of 1-octene were reacted with 330 g (7.17 mol) of formic acid and 232 g (3.41 mol) of a 50% strength aqueous H2O2 solution in accordance with Example 4. 575 g of ethanol were employed for the Marlon AS3 acid-catalyzed transesterification, and the main fraction obtained after the workup by distillation was >99.5% pure, virtually odorless 1,2-octanediol. the main fraction obtained after the workup by distillation

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Racemic 2-n-hexyl-2,3-dihydro-thieno[3,4-b][1,4]dioxine was synthesized by transetherification of 3,4-dimethoxythiophene with racemic 1,2-octanediol as described in EXAMPLE 1. It was characterized by GC-MS and 1H-NMR-spectroscopy, and exhibited no optical rotation.