N-methoxy-2-phenylacetamide

反応条件: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Dissolve 1.65 g (10 mmol) of N-(methoxy)-phenylacetamide in 30 cm3 of dry chloroform. Place in an ice-bath and maintain at a temperature of 0° C. Subsequently, pour in progressively, using a flask, 1.30 g (1.36 cm3, 12 mmol) of tert-butyl hypochlorite which has previously been dissolved in 20 cm3 of chloroform. Place in an ice-bath Subsequently, pour in progressively,

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Introduce into a round-bottomed flask 6.8 g (50 mmol) of phenylacetic acid and 4.6 g (55 mmol) of methoxylamine hydrochloride, 5.55 g (55 mmol) of triethylamine and finally 10.83 g (52.5 mmol) of N,N-dicyclohexylcarbodiimide. Dissolve in 150 cm3 of dichloromethane. Stir for 16 hours at room temperature. Remove the precipitate by means of filtration and wash it with dichloromethane. Treat the filtrate with 100 cm3 of 3% HCl, then with 100 cm3 of water and finally with 100 cm3 of 5% NaHCO3. Remove the precipitate by means of filtration wash it with dichloromethane Treat the filtrate with 100 cm3 of 3% HCl