表示可能な構造データがありません
C1=CC(=C(C(=C1)Cl)OC(F)F)F製品情報
1-chloro-2-(difluoromethoxy)-3-fluorobenzene (CAS 1136961-91-5) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
想定用途
専門的研究・工業用途限定
データベース ID 59432130
安全上の注意
For professional research and industrial use only. Review the supplier safety data sheet before handling.
合成データ
10 反応 · 10 文献
反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-fa5a27243b594e05b163ca5d498340f0反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 2-Chloro-6-fluorophenol (1.8 g, 12.33 mmol) was dissolved in dimethylformamide (DMF; 22 mL) and water (2.2 mL). Potassium carbonate (2.55 g, 18.5 mmol) and sodium chlorodifluoroacetate (4.7 g, 30.8 mmol) were then added and the solution was heated to 100° C. for 3 h. The cooled reaction mixture was then diluted with concentrated HCl (10 mL) and the resulting solution was stirred for 2 h. The reaction mixture was diluted with diethyl ether, washed with water, washed twice with 1M NaOH, washed once with brine, dried, filtered and concentrated under vacuum to yield the title compound (1 g, 41% yield) that was used in subsequent reactions without further purification. The cooled reaction mixture washed with water washed twice with 1M NaOH washed once with brine dried filtered concentrated under vacuum
ソース ID: ord-0265a73d97804f28b16f58482a289d12反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 2-Chloro-6-fluorophenol (1.8 g, 12.33 mmol) was dissolved in dimethylformamide (DMF; 22 mL) and water (2.2 mL). Potassium carbonate (2.55 g, 18.5 mmol) and sodium chlorodifluoroacetate (4.7 g, 30.8 mmol) were then added and the solution was heated to 100° C. for 3 h. The cooled reaction mixture was then diluted with concentrated HCl (10 mL) and the resulting solution was stirred for 2 h. The reaction mixture was diluted with diethyl ether, washed with water, washed twice with 1M NaOH, washed once with brine, dried, filtered and concentrated under vacuum to yield the title compound (1 g, 41% yield) that was used in subsequent reactions without further purification. The cooled reaction mixture washed with water washed twice with 1M NaOH washed once with brine dried filtered concentrated under vacuum
ソース ID: ord-0265a73d97804f28b16f58482a289d12反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 2-Chloro-6-fluorophenol (1.8 g, 12.33 mmol) was dissolved in dimethylformamide (DMF; 22 mL) and water (2.2 mL). Potassium carbonate (2.55 g, 18.5 mmol) and sodium chlorodifluoroacetate (4.7 g, 30.8 mmol) were then added and the solution was heated to 100° C. for 3 h. The cooled reaction mixture was then diluted with concentrated HCl (10 mL) and the resulting solution was stirred for 2 h. The reaction mixture was diluted with diethyl ether, washed with water, washed twice with 1M NaOH, washed once with brine, dried, filtered and concentrated under vacuum to yield the title compound (1 g, 41% yield) that was used in subsequent reactions without further purification. The cooled reaction mixture washed with water washed twice with 1M NaOH washed once with brine dried filtered concentrated under vacuum
ソース ID: ord-83e498dbeb574459a12df048f5e279e9反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 2-Chloro-6-fluorophenol (1.8 g, 12.33 mmol) was dissolved in dimethylformamide (DMF; 22 mL) and water (2.2 mL). Potassium carbonate (2.55 g, 18.5 mmol) and sodium chlorodifluoroacetate (4.7 g, 30.8 mmol) were then added and the solution was heated to 100° C. for 3 h. The cooled reaction mixture was then diluted with concentrated HCl (10 mL) and the resulting solution was stirred for 2 h. The reaction mixture was diluted with diethyl ether, washed with water, washed twice with 1M NaOH, washed once with brine, dried, filtered and concentrated under vacuum to yield the title compound (1 g, 41% yield) that was used in subsequent reactions without further purification. The cooled reaction mixture washed with water washed twice with 1M NaOH washed once with brine dried filtered concentrated under vacuum
ソース ID: ord-0265a73d97804f28b16f58482a289d12反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 2-Chloro-6-fluorophenol (1.8 g, 12.33 mmol) was dissolved in dimethylformamide (DMF; 22 mL) and water (2.2 mL). Potassium carbonate (2.55 g, 18.5 mmol) and sodium chlorodifluoroacetate (4.7 g, 30.8 mmol) were then added and the solution was heated to 100° C. for 3 h. The cooled reaction mixture was then diluted with concentrated HCl (10 mL) and the resulting solution was stirred for 2 h. The reaction mixture was diluted with diethyl ether, washed with water, washed twice with 1M NaOH, washed once with brine, dried, filtered and concentrated under vacuum to yield the title compound (1 g, 41% yield) that was used in subsequent reactions without further purification. The cooled reaction mixture washed with water washed twice with 1M NaOH washed once with brine dried filtered concentrated under vacuum
ソース ID: ord-d2ef127d5897493abdb2283a2419c2a5反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 2-Chloro-6-fluorophenol (1.8 g, 12.33 mmol) was dissolved in dimethylformamide (DMF; 22 mL) and water (2.2 mL). Potassium carbonate (2.55 g, 18.5 mmol) and sodium chlorodifluoroacetate (4.7 g, 30.8 mmol) were then added and the solution was heated to 100° C. for 3 h. The cooled reaction mixture was then diluted with concentrated HCl (10 mL) and the resulting solution was stirred for 2 h. The reaction mixture was diluted with diethyl ether, washed with water, washed twice with 1M NaOH, washed once with brine, dried, filtered and concentrated under vacuum to yield the title compound (1 g, 41% yield) that was used in subsequent reactions without further purification. The cooled reaction mixture washed with water washed twice with 1M NaOH washed once with brine dried filtered concentrated under vacuum
ソース ID: ord-d2ef127d5897493abdb2283a2419c2a5反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 2-Chloro-6-fluorophenol (1.8 g, 12.33 mmol) was dissolved in dimethylformamide (DMF; 22 mL) and water (2.2 mL). Potassium carbonate (2.55 g, 18.5 mmol) and sodium chlorodifluoroacetate (4.7 g, 30.8 mmol) were then added and the solution was heated to 100° C. for 3 h. The cooled reaction mixture was then diluted with concentrated HCl (10 mL) and the resulting solution was stirred for 2 h. The reaction mixture was diluted with diethyl ether, washed with water, washed twice with 1M NaOH, washed once with brine, dried, filtered and concentrated under vacuum to yield the title compound (1 g, 41% yield) that was used in subsequent reactions without further purification. The cooled reaction mixture washed with water washed twice with 1M NaOH washed once with brine dried filtered concentrated under vacuum
ソース ID: ord-d2ef127d5897493abdb2283a2419c2a5反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 2-Chloro-6-fluorophenol (1.8 g, 12.33 mmol) was dissolved in dimethylformamide (DMF; 22 mL) and water (2.2 mL). Potassium carbonate (2.55 g, 18.5 mmol) and sodium chlorodifluoroacetate (4.7 g, 30.8 mmol) were then added and the solution was heated to 100° C. for 3 h. The cooled reaction mixture was then diluted with concentrated HCl (10 mL) and the resulting solution was stirred for 2 h. The reaction mixture was diluted with diethyl ether, washed with water, washed twice with 1M NaOH, washed once with brine, dried, filtered and concentrated under vacuum to yield the title compound (1 g, 41% yield) that was used in subsequent reactions without further purification. The cooled reaction mixture washed with water washed twice with 1M NaOH washed once with brine dried filtered concentrated under vacuum
ソース ID: ord-83e498dbeb574459a12df048f5e279e9反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 2-Chloro-6-fluorophenol (1.8 g, 12.33 mmol) was dissolved in dimethylformamide (DMF; 22 mL) and water (2.2 mL). Potassium carbonate (2.55 g, 18.5 mmol) and sodium chlorodifluoroacetate (4.7 g, 30.8 mmol) were then added and the solution was heated to 100° C. for 3 h. The cooled reaction mixture was then diluted with concentrated HCl (10 mL) and the resulting solution was stirred for 2 h. The reaction mixture was diluted with diethyl ether, washed with water, washed twice with 1M NaOH, washed once with brine, dried, filtered and concentrated under vacuum to yield the title compound (1 g, 41% yield) that was used in subsequent reactions without further purification. The cooled reaction mixture washed with water washed twice with 1M NaOH washed once with brine dried filtered concentrated under vacuum
ソース ID: ord-0265a73d97804f28b16f58482a289d12PubChem References
化合物の公開データベース記録に掲載された情報源です。
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