(2R)-2-amino-1-pyrrolidin-1-ylpropan-1-one

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Phenylmethyl [(1R)-1-methyl-2-oxo-2-(1-pyrrolidinyl)ethyl]carbamate (496 mg, 1.8 mmol) was dissolved in 20 mL of MeOH, degassed and placed under argon. 10% Pd/C (125 mg) was added, and the contents were thoroughly degassed and placed under a hydrogen balloon overnight. The contents were then degassed and filtered through Celite, and the Celite pad was washed with DCM and MeOH. The resulting filtrate was concentrated in vacuo to provide the (2R)-1-oxo-1-(1-pyrrolidinyl)-2-propanamine (235 mg, 91%). LCMS: (M+H)+: 143.1. degassed 10% Pd/C (125 mg) was added the contents were thoroughly degassed balloon overnight The contents were then degassed filtered through Celite the Celite pad was washed with DCM and MeOH The resulting filtrate was concentrated in vacuo