N-(8-amino-2-oxo-3,4-dihydro-1H-quinolin-3-yl)acetamide

反応条件: temp:110.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: N-(8-Amino-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)acetamide (8.4 g) was added to concentrated hydrochloric acid (84 mL), and the mixture was heated at 110° C. for three hours while being stirred, followed by stirring under cooling on ice. The formed precipitates were recovered through filtration, and the thus-obtained solid was washed with ethanol, followed by drying, whereby the title compound (9.17 g) was yielded. by stirring under cooling on ice The formed precipitates were recovered through filtration the thus-obtained solid was washed with ethanol by drying

反応条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: N-(6-Bromo-8-nitro-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)acetamide (15 g) was suspended in ethanol (150 mL), and ammonium formate (28.8 g) and 10% Pd—C (water content: 53%) (1.5 g) were added thereto. The mixture was heated at 80° C. while being stirred for 30 minutes, and water (150 mL) and ethanol (150 mL) were added thereto, followed by filtration while being heated. The filtrate was concentrated under reduced pressure, and the formed precipitates were recovered through filtration. The thus-obtained solid was washed with ethanol and diisopropyl ether, followed by drying, whereby the title compound (8.5 g) was yielded. followed by filtration while being heated The filtrate was concentrated under reduced pressure the formed precipitates were recovered through filtration The thus-obtained solid was washed with ethanol and diisopropyl ether by drying

反応条件: temp:110.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: N-(8-Amino-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)acetamide (8.4 g) was added to concentrated hydrochloric acid (84 mL), and the mixture was heated at 110° C. for three hours while being stirred, followed by stirring under cooling on ice. The formed precipitates were recovered through filtration, and the thus-obtained solid was washed with ethanol, followed by drying, whereby the title compound (9.17 g) was yielded. by stirring under cooling on ice The formed precipitates were recovered through filtration the thus-obtained solid was washed with ethanol by drying

反応条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: N-(6-Bromo-8-nitro-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)acetamide (15 g) was suspended in ethanol (150 mL), and ammonium formate (28.8 g) and 10% Pd—C (water content: 53%) (1.5 g) were added thereto. The mixture was heated at 80° C. while being stirred for 30 minutes, and water (150 mL) and ethanol (150 mL) were added thereto, followed by filtration while being heated. The filtrate was concentrated under reduced pressure, and the formed precipitates were recovered through filtration. The thus-obtained solid was washed with ethanol and diisopropyl ether, followed by drying, whereby the title compound (8.5 g) was yielded. followed by filtration while being heated The filtrate was concentrated under reduced pressure the formed precipitates were recovered through filtration The thus-obtained solid was washed with ethanol and diisopropyl ether by drying