ethyl 4-(chloromethyl)benzoate

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of intermediate 25 (200 mg, 0.786 mmol) and 4-chloromethylbenzoic acid ethyl ester (0.268 mg, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 278 mg of the product 205. 1H NMR (DMSO-d6) δ 11.20 (s, 2 H), 8.00 (d, 2 H), 7.75 (d, 2 H), 7.15-6.90 (m, 6 H), 6.90-6.65 (m, 4 H), 5.78 (s, 2 H), 4.90 (s, 2 H), 4.35 (q, 2 H), 1.32 (t, 3 H); MS: m/z 417 (M++1). evaporated to dryness The insoluble material is filtered

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of intermediate 25 (200 mg, 0.786 mmol) and 4-chloromethylbenzoic acid ethyl ester (0.268 mg, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 278 mg of the product 205. 1H NMR (DMSO-d6) δ 11.20 (s, 2 H), 8.00 (d, 2 H), 7.75 (d, 2 H), 7.15-6.90 (m, 6 H), 6.90-6.65 (m, 4 H), 5.78 (s, 2 H), 4.90 (s, 2 H), 4.35 (q, 2 H), 1.32 (t, 3 H); MS: m/z 417 (M++1). evaporated to dryness The insoluble material is filtered

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of intermediate 25 (200 mg, 0.786 mmol) and 4-chloromethylbenzoic acid ethyl ester (0.268 mg, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 278 mg of the product 205. 1H NMR (DMSO-d6) δ 11.20 (s, 2H), 8.00 (d, 2H), 7.75 (d, 2H), 7.15-6.90 (m, 6H), 6.90-6.65 (m, 4H), 5.78 (s, 2H), 4.90 (s, 2H), 4.35 (q, 2H), 1.32 (t, 3H); MS: m/z 417 (M++1). evaporated to dryness The insoluble material is filtered

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of intermediate 25 (200 mg, 0.786 mmol) and 4-chloromethylbenzoic acid ethyl ester (0.268 mg, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 278 mg of the product 205. 1H NMR (DMSO-d6) δ 11.20 (s, 2 H), 8.00 (d, 2 H), 7.75 (d, 2 H), 7.15-6.90 (m, 6 H), 6.90-6.65 (m, 4 H), 5.78 (s, 2 H), 4.90 (s, 2 H), 4.35 (q, 2 H), 1.32 (t, 3 H); MS: m/z 417 (M++1). evaporated to dryness The insoluble material is filtered