N,N-diethylpiperidin-3-amine;dihydrochloride

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and N,N-diethylpiperidin-3-amine dihydrochloride. 1H NMR (500 MHz, CHLOROFORM-d) δ ppm 1.26 (br. s., 6 H) 1.57 (br. s., 2 H) 1.76-2.17 (m, 2 H) 2.36-2.90 (m, 9 H) 3.02 (br. s., 1 H) 3.70 (br. s., 1 H) 4.52-4.92 (m, 1 H) 7.48-7.60 (m, 3 H) 7.63-7.73 (m, 1 H) 7.95-8.10 (m, 2 H) 8.43 (s, 1 H); ESI-MS m/z [M+H]+ 459.3.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and N,N-diethylpiperidin-3-amine dihydrochloride. 1H NMR (500 MHz, CHLOROFORM-d) δ ppm 1.26 (br. s., 6H) 1.57 (br. s., 2H) 1.76-2.17 (m, 2H) 2.36-2.90 (m, 9H) 3.02 (br. s., 1H) 3.70 (br. s., 1H) 4.52-4.92 (m, 1H) 7.48-7.60 (m, 3H) 7.63-7.73 (m, 1H) 7.95-8.10 (m, 2H) 8.43 (s, 1H); ESI-MS m/z [M+H]+ 459.3.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and N,N-diethylpiperidin-3-amine dihydrochloride. 1H NMR (500 MHz, CHLOROFORM-d) δ ppm 1.26 (br. s., 6 H) 1.57 (br. s., 2 H) 1.76-2.17 (m, 2 H) 2.36-2.90 (m, 9 H) 3.02 (br. s., 1 H) 3.70 (br. s., 1 H) 4.52-4.92 (m, 1 H) 7.48-7.60 (m, 3 H) 7.63-7.73 (m, 1 H) 7.95-8.10 (m, 2 H) 8.43 (s, 1 H); ESI-MS m/z [M+H]+ 459.3.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and N,N-diethylpiperidin-3-amine dihydrochloride. 1H NMR (500 MHz, CHLOROFORM-d) δ ppm 1.26 (br. s., 6H) 1.57 (br. s., 2H) 1.76-2.17 (m, 2H) 2.36-2.90 (m, 9H) 3.02 (br. s., 1H) 3.70 (br. s., 1H) 4.52-4.92 (m, 1H) 7.48-7.60 (m, 3H) 7.63-7.73 (m, 1H) 7.95-8.10 (m, 2H) 8.43 (s, 1H); ESI-MS m/z [M+H]+ 459.3.