2-fluoro-4-[(4-methoxyphenyl)methoxy]benzonitrile

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 4-Methoxybenzyl chloride (5.0 g) and potassium carbonate (8.3 g) were added to an acetone (0.5 L) solution of 2-fluoro-4-hydroxybenzonitrile (4.1 g), and stirred with heating under reflux for 15 hours. After cooled to room temperature, the reaction solution was evaporated under reduced pressure, water (50 mL) was added to the residue, extracted with ethyl acetate, dried with sodium sulfate and concentrated under reduced pressure. The crude product was purified through silica gel column chromatography (hexane/ethyl acetate) to give the title compound as a white solid (7.2 g). with heating under reflux for 15 hours the reaction solution was evaporated under reduced pressure, water (50 mL) was added to the residue extracted with ethyl acetate dried with sodium sulfate concentrated under reduced pressure The crude product was purified through silica gel column chromatography (hexane/ethyl acetate)