1,2-difluoro-3-propoxybenzene

反応条件: temp:-40.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 65 ml of a solution of 0.1 mol of n-butyllithium in hexane is added at -100° C. to a mixture of 0.1 mol of 4- propoxy-2,3-difluorobenzene, 0.09 mol of potassium tert.butylate and 250 ml of tetrahydrofuran. After stirring for 10 minutes a mixture of 0.1 mole of trans-4-(trans-4-propylcyclohexylethyl)-cyclohexylethyl iodide, 0.1 mol of N,N-dimethylpropyleneurea and 100 ml of tetrahydrofuran is added to the mixture. Stirring for 1 hour at -85° C., warming up to -40° C. and working up in the customary manner gives trans-4-(2-(4-propoxy-2,3-difluorophenyl)-ethyl)-1-(2-(trans-4-propylcyclohexyl)ethyl)-cyclohexane. is added to the mixture Stirring for 1 hour at -85° C.

反応条件: temp:-40.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 65 ml of a solution of 0.1 mol of n-butyllithium in hexane is added at -100° C. to a mixture of 0.1 mol of 4- propoxy-2,3-difluorobenzene, 0.09 mol of potassium tert.butylate and 250 ml of tetrahydrofuran. After stirring for 10 minutes a mixture of 0.1 mole of trans-4-(trans-4-propylcyclohexylethyl)-cyclohexylethyl iodide, 0.1 mol of N,N-dimethylpropyleneurea and 100 ml of tetrahydrofuran is added to the mixture. Stirring for 1 hour at -85° C., warming up to -40° C. and working up in the customary manner gives trans-4-(2-(4-propoxy-2,3-difluorophenyl)-ethyl)-1-(2-(trans-4-propylcyclohexyl)ethyl)-cyclohexane. is added to the mixture Stirring for 1 hour at -85° C.

反応条件: temp:-40.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 65 ml of a solution of 0.1 mol of n-butyllithium in hexane is added at -100° C. to a mixture of 0.1 mol of 4- propoxy-2,3-difluorobenzene, 0.09 mol of potassium tert.butylate and 250 ml of tetrahydrofuran. After stirring for 10 minutes a mixture of 0.1 mole of trans-4-(trans-4-propylcyclohexylethyl)-cyclohexylethyl iodide, 0.1 mol of N,N-dimethylpropyleneurea and 100 ml of tetrahydrofuran is added to the mixture. Stirring for 1 hour at -85° C., warming up to -40° C. and working up in the customary manner gives trans-4-(2-(4-propoxy-2,3-difluorophenyl)-ethyl)-1-(2-(trans-4-propylcyclohexyl)ethyl)-cyclohexane. is added to the mixture Stirring for 1 hour at -85° C.