1-[benzyl(2-hydroxyethyl)amino]butan-2-ol

反応条件: temp:140.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To 1-(benzyl(2-hydroxyethyl)amino)butan-2-ol (2.9 g, 12.99 mmol) was added 70% H2SO4 (15 mL) and the resulting solution was heated at 140° C. for 17 h. The mixture was brough to RT, cooled to 0° C. and made alkaline with 50% NaOH. The resulting solution was diluted in water and extracted with DCM. The combined organics were dried over Na2SO4, filtered and concentrated to afford 4-benzyl-2-ethylmorpholine as a light orange oil that was used without further purification. was brough to RT cooled to 0° C. extracted with DCM The combined organics were dried over Na2SO4 filtered concentrated

反応条件: temp:140.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To 1-(benzyl(2-hydroxyethyl)amino)butan-2-ol (2.9 g, 12.99 mmol) was added 70% H2SO4 (15 mL) and the resulting solution was heated at 140° C. for 17 h. The mixture was brough to RT, cooled to 0° C. and made alkaline with 50% NaOH. The resulting solution was diluted in water and extracted with DCM. The combined organics were dried over Na2SO4, filtered and concentrated to afford 4-benzyl-2-ethylmorpholine as a light orange oil that was used without further purification. was brough to RT cooled to 0° C. extracted with DCM The combined organics were dried over Na2SO4 filtered concentrated