2-(2-chloro-4-methoxyphenyl)acetaldehyde

反応条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a solution of (2-chloro-4-methoxyphenyl)acetaldehyde (1.22 g) in toluene (30.0 mL) was added tert-butyl (triphenylphosphoranylidene)acetate (2.75 g), followed by stirring at 80° C. overnight. The reaction mixture was air-cooled to room temperature, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane-ethyl acetate) to obtain tert-butyl (2E)-4-(2-chloro-4-methoxyphenyl)but-2-enoate (1.67 g). The reaction mixture was air-cooled to room temperature concentrated under reduced pressure The residue was purified by silica gel column chromatography (hexane-ethyl acetate)