2-Chloro-1-(2,4,5-trifluorophenyl)ethanone

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 40.8 g (0 3 mol) of sulphuryl chloride were added dropwise at room temperature (22° C.) to 48 g (0.275 mol) of 2,4,5-trifluoroacetophenone (obtained according to Example 110)dissolved in 400 ml of dichloromethane and the mixture was stirred until evolution of hydrogen chloride had ended (about 2 hours). The reaction mixture was then added to 600 ml of water, the organic phase was separated off, this was washed until neutral with sodium hydrogen carbonate solution and dried over magnesium sulphate, and the solvent was stripped off in a water pump vacuum. 48.6 g of 2,4,5-trifluorophenacyl chloride were obtained as an oily residue, which corresponds to 84.5% of theory. The characterization of the product carried out as in Examples 113 to 119 yielded a & value of 5.29 ppm. obtained (about 2 hours) the organic phase was separated off this was washed until neutral with sodium hydrogen carbonate solution dried over magnesium sulphate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 40.8 g (0.3 mole) of sulphuryl chloride were added dropwise at room temperature (22° C.) to 48 g (0.275 mole) of 2,4,5-trifluoroacetophenone (obtained according to Example 6), dissolved in 400 ml of dichloromethane, and the mixture was stirred until the end of the evolution of hydrogen chloride (about 2 hours). 600 ml of water were then added to the reaction mixture, the organic phase was separated off, and this was washed until neutral with sodium hydrogen carbonate solution and dried over magnesium sulphate, and the solvent was stripped off in a water pump vacuum. 48.6 g of 2,4,5- trifluoro-phenacyl chloride were obtained as an oily residue, which corresponds to 84.5 % of theory. The characterization of the product carried out as in Examples 9 to 15 gave a δ value of 5.29 ppm. the organic phase was separated off this was washed until neutral with sodium hydrogen carbonate solution dried over magnesium sulphate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 40.8 g (0 3 mol) of sulphuryl chloride were added dropwise at room temperature (22° C.) to 48 g (0.275 mol) of 2,4,5-trifluoroacetophenone (obtained according to Example 110)dissolved in 400 ml of dichloromethane and the mixture was stirred until evolution of hydrogen chloride had ended (about 2 hours). The reaction mixture was then added to 600 ml of water, the organic phase was separated off, this was washed until neutral with sodium hydrogen carbonate solution and dried over magnesium sulphate, and the solvent was stripped off in a water pump vacuum. 48.6 g of 2,4,5-trifluorophenacyl chloride were obtained as an oily residue, which corresponds to 84.5% of theory. The characterization of the product carried out as in Examples 113 to 119 yielded a & value of 5.29 ppm. obtained (about 2 hours) the organic phase was separated off this was washed until neutral with sodium hydrogen carbonate solution dried over magnesium sulphate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 40.8 g (0.3 mole) of sulphuryl chloride were added dropwise at room temperature (22° C.) to 48 g (0.275 mole) of 2,4,5-trifluoroacetophenone (obtained according to Example 6), dissolved in 400 ml of dichloromethane, and the mixture was stirred until the end of the evolution of hydrogen chloride (about 2 hours). 600 ml of water were then added to the reaction mixture, the organic phase was separated off, and this was washed until neutral with sodium hydrogen carbonate solution and dried over magnesium sulphate, and the solvent was stripped off in a water pump vacuum. 48.6 g of 2,4,5- trifluoro-phenacyl chloride were obtained as an oily residue, which corresponds to 84.5 % of theory. The characterization of the product carried out as in Examples 9 to 15 gave a δ value of 5.29 ppm. the organic phase was separated off this was washed until neutral with sodium hydrogen carbonate solution dried over magnesium sulphate