ethyl 3-phenyloxirane-2-carboxylate

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The title compound was synthesized using a literature method (Legters, J.; Thijs, L.; Zwanenburg, B. Tetrahedron Lett. 1989, 30, 4881). To a mixture of 3-phenyloxirane-2-carboxylic acid ethyl ester (9.6 ml, 55 mmol) and 183 ml of EtOH in a flame-dried two-necked flask equipped with a water condenser and magnetic stirring rod was added NaN3 (10.73 g, 165 mmol) and ammonium chloride (8.83 g, 165 mmol). The reaction mixture was brought to 65° C. and stirred for 5 hours at which point GC analysis showed that the reaction was complete. The mixture was filtered and concentrated under reduced pressure. The crude 1H NMR showed that the product of nucleophilic opening of the epoxide by azide was pure enough to carry over to the next step. In a flame-dried two-neck flask fitted with a water condenser and equipped with a magnetic stirring bar was added the product from above (12.93 g, 55 mmol) dissolved in 183 ml of acetonitrile. The reaction mixture was brought to 40° C., at which point PPh3 (16 g, 61 mmol) was added slow enough to avoid rapid evolution of N2. The reaction was then brought to 83° C. and stirred for 5 hours. The reaction mixture was then cooled and concentrated under reduced pressure. The crude mixture was then dissolved in 5% EtOAc in pentane and filtered. The filtrate was concentrated and subsequently dissolved in pentane and placed in the freezer overnight (−15° C.). Any resulting precipitate that formed was filtered off and the filtrate was concentrated under reduced pressure and subjected to silica gel column chromatography (eluent 20% EtOAc in hexanes) to yield a pale yellow oil in 61% over two steps. 1H NMR (200 MHz. CDCl3) (δ: 7.36-7.25 (m, 5H), 4.25 (qd, J=7 Hz, 1.2 Hz, 2H), 3.25 (s, 1H), 2.58 (s, 1H), 1.89 (bs, 1H), 1.31 (t, J=7 Hz, 3H) ppm. 13C NMR (75 MHz. CDCl3) δ: 171.6, 137.8, 128.3, 127.6, 126.1, 61.6, 40.2, 39.3, 14.0 ppm. equipped with a water condenser was brought to 65° C. The mixture was filtered concentrated under reduced pressure In a flame-dried two-neck flask fitted with a water condenser equipped with a magnetic stirring bar was added the product from above (12.93 g, 55 mmol) dissolved in 183 ml of acetonitrile was added slow enough was then brought to 83° C. stirred for 5 hours The reaction mixture was then cooled concentrated under reduced pressure The crude mixture was then dissolved in 5% EtOAc in pentane filtered The filtrate was concentrated subsequently dissolved in pentane placed in the freezer overnight (−15° C.) Any resulting precipitate that formed was filtered off the filtrate was concentrated under reduced pressure to yield a pale yellow oil in 61% over two steps

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a stirred mixture of 4-methoxy-2-nitrophenol (11.87 g, 70 mmol), ethyl 3-phenyloxirane-2-carboxylate (10.39 g, 54 mmol) and ethanol (175 mL) was added portionwise 60% sodium hydride (0.65 g, 16 mmol) and the red mixture stirred at reflux for 9 days. The solvent was removed in vacuo, the residue dissolved in ethyl acetate and extracted three times with 10% aqueous potassium carbonate. The organic layer was washed with water and brine, dried (MgSO4), filtered and the solvent stripped in-vacuo to yield an oil. Column chromatography (dichloromethane then 5% methanol/dichloromethane) afforded (9.5 g, 49%) of slightly impure title compound that was used in the next step without further purification. 1H NMR (300 MHz, CDCl3) δ1.21 (t, 3H) 3.25 (d, 1H, J=7.5 Hz) 3.77 (s, 3H), 4.20 (q, 2H) 4.67 (q, 1H, J=3.5, 7.5 Hz), 5.51 (d, 1H, J=3.5 Hz), 6.82 (d, 1H, J=9.2 Hz), 6.92 (dd, 1H, J=9.2, 3.0 Hz), 7.3-7.4 (m, 6H). HPLC (Method A): 3.24 min. at reflux for 9 days The solvent was removed in vacuo the residue dissolved in ethyl acetate extracted three times with 10% aqueous potassium carbonate The organic layer was washed with water and brine dried (MgSO4) filtered to yield an oil

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a stirred mixture of 4-chloro-2-nitrophenol (11.68 g, 67.32 mmol), ethyl 3-phenyloxirane-2-carboxylate (9.61 g, 50.00 mmol) in ethanol (200 mL) was added portionwise 60% sodium hydride (738 mg, 20.00 mmol) and the red mixture stirred at reflux for 3 days. The solvent was removed in vacuo. The residue was dissolved in chloroform and extracted three times with 10% aqueous potassium carbonate. The organic layer was washed with water and brine, dried, filtered and evaporated to afford a brown residue. The residue was dissolved in a minimal volume of chloroform and precipitated by adding diethyl ether to afford the title compound (5.970 g, 33%) as an off-white solid. 1H NMR (300 MHz, DMSO-d6) δ1.16 (t, 3H, J=7.0 Hz), 4.09 (q, 2H, J=7.0 Hz), 4.29 (t, 1H, J=7.0 Hz), 5.63 (d, 1H, J=7.0 Hz), 6.09 (d, 1H, J=7.0 Hz), 7.19-7.60 (m, 7H), 7.97 (d, 1H, J=2.6 Hz). MS APCI, m/z=388 (M+Na). LC/MS: 2.78 min. at reflux for 3 days The solvent was removed in vacuo The residue was dissolved in chloroform extracted three times with 10% aqueous potassium carbonate The organic layer was washed with water and brine dried filtered evaporated to afford a brown residue precipitated by adding diethyl ether

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a stirred mixture of 4-chloro-2-nitrophenol (11.68 g, 67.32 mmol), ethyl 3-phenyloxirane-2-carboxylate (9.61 g, 50.00 mmol) in ethanol (200 mL) was added portionwise 60% sodium hydride (738 mg, 20.00 mmol) and the red mixture stirred at reflux for 3 days. The solvent was removed in vacuo. The residue was dissolved in chloroform and extracted three times with 10% aqueous potassium carbonate. The organic layer was washed with water and brine, dried, filtered and evaporated to afford a brown residue. The residue was dissolved in a minimal volume of chloroform and precipitated by adding diethyl ether to afford the title compound (5.970 g, 33%) as an off-white solid. 1H NMR (300 MHz, DMSO-d6) δ1.16 (t, 3H, J=7.0 Hz), 4.09 (q, 2H, J=7.0 Hz), 4.29 (t, 1H, J=7.0 Hz), 5.63 (d, 1H, J=7.0 Hz), 6.09 (d, 1H, J=7.0 Hz), 7.19-7.60 (m, 7H), 7.97 (d, 1H, J=2.6 Hz). MS APCI, m/z=388 (M+Na). LC/MS: 2.78 min. at reflux for 3 days The solvent was removed in vacuo The residue was dissolved in chloroform extracted three times with 10% aqueous potassium carbonate The organic layer was washed with water and brine dried filtered evaporated to afford a brown residue precipitated by adding diethyl ether

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a stirred mixture of 4-methoxy-2-nitrophenol (11.87 g, 70 mmol), ethyl 3-phenyloxirane-2-carboxylate (10.39 g, 54 mmol) and ethanol (175 mL) was added portionwise 60% sodium hydride (0.65 g, 16 mmol) and the red mixture stirred at reflux for 9 days. The solvent was removed in vacuo, the residue dissolved in ethyl acetate and extracted three times with 10% aqueous potassium carbonate. The organic layer was washed with water and brine, dried (MgSO4), filtered and the solvent stripped in-vacuo to yield an oil. Column chromatography (dichloromethane then 5% methanol/dichloromethane) afforded (9.5 g, 49%) of slightly impure title compound that was used in the next step without further purification. 1H NMR (300 MHz, CDCl3) δ1.21 (t, 3H) 3.25 (d, 1H, J=7.5 Hz) 3.77 (s, 3H), 4.20 (q, 2H) 4.67 (q, 1H, J=3.5, 7.5 Hz), 5.51 (d, 1H, J=3.5 Hz), 6.82 (d, 1H, J=9.2 Hz), 6.92 (dd, 1H, J=9.2, 3.0 Hz), 7.3-7.4 (m, 6H). HPLC (Method A): 3.24 min at reflux for 9 days The solvent was removed in vacuo the residue dissolved in ethyl acetate extracted three times with 10% aqueous potassium carbonate The organic layer was washed with water and brine dried (MgSO4) filtered to yield an oil

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a stirred mixture of 4-chloro-2-nitrophenol (11.68 g, 67.32 mmol), ethyl 3-phenyloxirane-2-carboxylate (9.61 g, 50.00 mmol) in ethanol (200 mL) was added portionwise 60% sodium hydride (738 mg, 20.00 mmol) and the red mixture stirred at reflux for 3 days. The solvent was removed in vacuo. The residue was dissolved in chloroform and extracted three times with 10% aqueous potassium carbonate. The organic layer was washed with water and brine, dried, filtered and evaporated to afford a brown residue. The residue was dissolved in a minimal volume of chloroform and precipitated by adding diethyl ether to afford the title compound (5.970 g,33%) as an off-white solid. 1H NMR (300 MHz, DMSO-d6) δ1.16 (t, 3H, J=7.0 Hz), 4.09 (q, 2H, J=7.0 Hz), 4.29 (t, 1H, J=7.0 Hz), 5.63 (d, 1H, J=7.0 Hz), 6.09 (d, 1H, J=7.0 Hz), 7.19-7.60 (m, 7H), 7.97 (d, 1H, J=2.6 Hz). MS APCI, m/z=388 (M+Na). at reflux for 3 days The solvent was removed in vacuo The residue was dissolved in chloroform extracted three times with 10% aqueous potassium carbonate The organic layer was washed with water and brine dried filtered evaporated to afford a brown residue precipitated by adding diethyl ether

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The title compound was synthesized using a literature method (Legters, J.; Thijs, L.; Zwanenburg, B. Tetrahedron Lett. 1989, 30, 4881). To a mixture of 3-phenyloxirane-2-carboxylic acid ethyl ester (9.6 ml, 55 mmol) and 183 ml of EtOH in a flame-dried two-necked flask equipped with a water condenser and magnetic stirring rod was added NaN3 (10.73 g, 165 mmol) and ammonium chloride (8.83 g, 165 mmol). The reaction mixture was brought to 65° C. and stirred for 5 hours at which point GC analysis showed that the reaction was complete. The mixture was filtered and concentrated under reduced pressure. The crude 1H NMR showed that the product of nucleophilic opening of the epoxide by azide was pure enough to carry over to the next step. In a flame-dried two-neck flask fitted with a water condenser and equipped with a magnetic stirring bar was added the product from above (12.93 g, 55 mmol) dissolved in 183 ml of acetonitrile. The reaction mixture was brought to 40° C., at which point PPh3 (16 g, 61 mmol) was added slow enough to avoid rapid evolution of N2. The reaction was then brought to 83° C. and stirred for 5 hours. The reaction mixture was then cooled and concentrated under reduced pressure. The crude mixture was then dissolved in 5% EtOAc in pentane and filtered. The filtrate was concentrated and subsequently dissolved in pentane and placed in the freezer overnight (−15° C.). Any resulting precipitate that formed was filtered off and the filtrate was concentrated under reduced pressure and subjected to silica gel column chromatography (eluent 20% EtOAc in hexanes) to yield a pale yellow oil in 61% over two steps. 1H NMR (200 MHz. CDCl3) (δ: 7.36-7.25 (m, 5H), 4.25 (qd, J=7 Hz, 1.2 Hz, 2H), 3.25 (s, 1H), 2.58 (s, 1H), 1.89 (bs, 1H), 1.31 (t, J=7 Hz, 3H) ppm. 13C NMR (75 MHz. CDCl3) δ: 171.6, 137.8, 128.3, 127.6, 126.1, 61.6, 40.2, 39.3, 14.0 ppm. equipped with a water condenser was brought to 65° C. The mixture was filtered concentrated under reduced pressure In a flame-dried two-neck flask fitted with a water condenser equipped with a magnetic stirring bar was added the product from above (12.93 g, 55 mmol) dissolved in 183 ml of acetonitrile was added slow enough was then brought to 83° C. stirred for 5 hours The reaction mixture was then cooled concentrated under reduced pressure The crude mixture was then dissolved in 5% EtOAc in pentane filtered The filtrate was concentrated subsequently dissolved in pentane placed in the freezer overnight (−15° C.) Any resulting precipitate that formed was filtered off the filtrate was concentrated under reduced pressure to yield a pale yellow oil in 61% over two steps