2-(oxetan-3-yl)ethanesulfonyl chloride

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Using the same reaction conditions and procedure as described for the preparation of Example 7A, 8-Amino-7-(2-fluoro-4-iodo-phenylamino)-6-methyl-2,3-dihydro-oxazolo[3,2-a]pyridin-5-one (I-7f: 0.2 g, 0.673 mmol) was reacted with 2-(oxetan-3-yl)ethanesulfonyl chloride (0.18 g, 1.009 mmol) in dry pyridine (3 mL) to afford the crude product. Purification by preparative HPLC, followed by flash column chromatography (3% methanol in chloroform) afforded 20 mg of the compound (17A) (9% yield) and 3 mg of the hydrolyzed by-product (compound (17B). the same reaction conditions and procedure to afford the crude product Purification by preparative HPLC