1-BENZYL-OCTAHYDRO-PYRROLO[3,4-B]PYRROLE

反応条件: temp:-78.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 1-Benzyl-3-oxo-azetidine (1.6 g, 10 mmol, 1.0 equiv), prepared as described in the literature (Katritzky, A. R.; Cundy, D. J.; J. Heterocyclic Chem. 1994, 31 271-275), was dissolved in dry MeOH and the solution was cooled to −78° C. Gaseous ammonia was was bubbled through the solution for 30 mins at which time 3 angstrom molecular sieves were added and the mixture transferred to a pressure tube. The solution was heated for 30 min at 60° C. The mixture was cooled to −78° C., the tube opened and KCN (0.65 g, 10 mmol, 1.0 equiv) and NH4Cl (0.27 g, 5 mmol, 0.5 equiv) were added and the tube was resealed and heated at 60° C. for 4 h. The reaction mixture was filtered and the filtrate was evaporated. The crude residue was purified by flash chromatography using 2% MeOH in CH2Cl2 to give the desired product (0.11 g, 6%) as a brown oil; MS, m/z 188=M+1. Gaseous ammonia was was bubbled through the solution for 30 mins at which time 3 angstrom molecular sieves were added the mixture transferred to a pressure tube The solution was heated for 30 min at 60° C The mixture was cooled to −78° C. heated at 60° C. for 4 h The reaction mixture was filtered the filtrate was evaporated The crude residue was purified by flash chromatography

反応条件: temp:-78.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 1-Benzyl-3-oxo-azetidine (1.6 g, 10 mmol, 1.0 equiv), prepared as described in the literature (Katritzky, A. R.; Cundy, D. J.; J. Heterocyclic Chem. 1994, 31 271-275), was dissolved in dry MeOH and the solution was cooled to −78° C. Gaseous ammonia was was bubbled through the solution for 30 mins at which time 3 angstrom molecular sieves were added and the mixture transferred to a pressure tube. The solution was heated for 30 min at 60° C. The mixture was cooled to −78° C., the tube opened and KCN (0.65 g, 10 mmol, 1.0 equiv) and NH4Cl (0.27 g, 5 mmol, 0.5 equiv) were added and the tube was resealed and heated at 60° C. for 4 h. The reaction mixture was filtered and the filtrate was evaporated. The crude residue was purified by flash chromatography using 2% MeOH in CH2Cl2 to give the desired product (0.11 g, 6%) as a brown oil; MS, m/z 188=M+1. Gaseous ammonia was was bubbled through the solution for 30 mins at which time 3 angstrom molecular sieves were added the mixture transferred to a pressure tube The solution was heated for 30 min at 60° C The mixture was cooled to −78° C. heated at 60° C. for 4 h The reaction mixture was filtered the filtrate was evaporated The crude residue was purified by flash chromatography

反応条件: temp:-78.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 1-Benzyl-3-oxo-azetidine (1.6 g, 10 mmol, 1.0 equiv), prepared as described in the literature (Katritzky, A. R.; Cundy, D. J.; J. Heterocyclic Chem. 1994, 31 271-275), was dissolved in dry MeOH and the solution was cooled to −78° C. Gaseous ammonia was was bubbled through the solution for 30 mins at which time 3 angstrom molecular sieves were added and the mixture transferred to a pressure tube. The solution was heated for 30 min at 60° C. The mixture was cooled to −78° C., the tube opened and KCN (0.65 g, 10 mmol, 1.0 equiv) and NH4Cl (0.27 g, 5 mmol, 0.5 equiv) were added and the tube was resealed and heated at 60° C. for 4 h. The reaction mixture was filtered and the filtrate was evaporated. The crude residue was purified by flash chromatography using 2% MeOH in CH2Cl2 to give the desired product (0.11 g, 6%) as a brown oil; MS, m/z 188=M+1. Gaseous ammonia was was bubbled through the solution for 30 mins at which time 3 angstrom molecular sieves were added the mixture transferred to a pressure tube The solution was heated for 30 min at 60° C The mixture was cooled to −78° C. heated at 60° C. for 4 h The reaction mixture was filtered the filtrate was evaporated The crude residue was purified by flash chromatography

反応条件: temp:-78.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 1-Benzyl-3-oxo-azetidine (1.6 g, 10 mmol, 1.0 equiv), prepared as described in the literature (Katritzky, A. R.; Cundy, D. J.; J. Heterocyclic Chem. 1994, 31 271-275), was dissolved in dry MeOH and the solution was cooled to −78° C. Gaseous ammonia was was bubbled through the solution for 30 mins at which time 3 angstrom molecular sieves were added and the mixture transferred to a pressure tube. The solution was heated for 30 min at 60° C. The mixture was cooled to −78° C., the tube opened and KCN (0.65 g, 10 mmol, 1.0 equiv) and NH4Cl (0.27 g, 5 mmol, 0.5 equiv) were added and the tube was resealed and heated at 60° C. for 4 h. The reaction mixture was filtered and the filtrate was evaporated. The crude residue was purified by flash chromatography using 2% MeOH in CH2Cl2 to give the desired product (0.11 g, 6%) as a brown oil; MS, m/z 188=M+1. Gaseous ammonia was was bubbled through the solution for 30 mins at which time 3 angstrom molecular sieves were added the mixture transferred to a pressure tube The solution was heated for 30 min at 60° C The mixture was cooled to −78° C. heated at 60° C. for 4 h The reaction mixture was filtered the filtrate was evaporated The crude residue was purified by flash chromatography

反応条件: temp:-78.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 1-Benzyl-3-oxo-azetidine (1.6 g, 10 mmol, 1.0 equiv), prepared as described in the literature (Katritzky, A. R.; Cundy, D. J.; J. Heterocyclic Chem. 1994, 31 271–275), was dissolved in dry MeOH and the solution was cooled to −78° C. Gaseous ammonia was was bubbled through the solution for 30 mins at which time 3 angstrom molecular sieves were added and the mixture transferred to a pressure tube. The solution was heated for 30 min at 60° C. The mixture was cooled to −78° C., the tube opened and KCN (0.65 g, 10 mmol, 1.0 equiv) and NH4Cl (0.27 g, 5 mmol, 0.5 equiv) were added and the tube was resealed and heated at 60° C. for 4 h. The reaction mixture was filtered and the filtrate was evaporated. The crude residue was purified by flash chromatography using 2% MeOH in CH2Cl2 to give the desired product (0.11 g, 6%) as a brown oil; MS, m/z 188=M+1. Gaseous ammonia was was bubbled through the solution for 30 mins at which time 3 angstrom molecular sieves were added the mixture transferred to a pressure tube The solution was heated for 30 min at 60° C The mixture was cooled to −78° C. heated at 60° C. for 4 h The reaction mixture was filtered the filtrate was evaporated The crude residue was purified by flash chromatography

反応条件: temp:-78.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 1-Benzyl-3-oxo-azetidine (1.6 g, 10 mmol, 1.0 equiv), prepared as described in the literature (Katritzky, A. R.; Cundy, D. J.; J. Heterocyclic Chem. 1994, 31 271-275), was dissolved in dry MeOH and the solution was cooled to −78° C. Gaseous ammonia was was bubbled through the solution for 30 mins at which time 3 angstrom molecular sieves were added and the mixture transferred to a pressure tube. The solution was heated for 30 min at 60° C. The mixture was cooled to −78° C., the tube opened and KCN (0.65 g, 10 mmol, 1.0 equiv) and NH4Cl (0.27 g, 5 mmol, 0.5 equiv) were added and the tube was resealed and heated at 60° C. for 4 h. The reaction mixture was filtered and the filtrate was evaporated. The crude residue was purified by flash chromatography using 2% MeOH in CH2Cl2 to give the desired product (0.11 g, 6%) as a brown oil; MS, m/z 188=M+1. Gaseous ammonia was was bubbled through the solution for 30 mins at which time 3 angstrom molecular sieves were added the mixture transferred to a pressure tube The solution was heated for 30 min at 60° C The mixture was cooled to −78° C. heated at 60° C. for 4 h The reaction mixture was filtered the filtrate was evaporated The crude residue was purified by flash chromatography

反応条件: temp:-78.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 1-Benzyl-3-oxo-azetidine (1.6 g, 10 mmol, 1.0 equiv), prepared as described in the literature (Katritzky, A. R.; Cundy, D. J.; J. Heterocyclic Chem. 1994, 31 271-275), was dissolved in dry MeOH and the solution was cooled to −78° C. Gaseous ammonia was was bubbled through the solution for 30 mins at which time 3 angstrom molecular sieves were added and the mixture transferred to a pressure tube. The solution was heated for 30 min at 60° C. The mixture was cooled to −78° C., the tube opened and KCN (0.65 g, 10 mmol, 1.0 equiv) and NH4Cl (0.27 g, 5 mmol, 0.5 equiv) were added and the tube was resealed and heated at 60° C. for 4 h. The reaction mixture was filtered and the filtrate was evaporated. The crude residue was purified by flash chromatography using 2% MeOH in CH2Cl2 to give the desired product (0.11 g, 6%) as a brown oil; MS, m/z 188=M+1. Gaseous ammonia was was bubbled through the solution for 30 mins at which time 3 angstrom molecular sieves were added the mixture transferred to a pressure tube The solution was heated for 30 min at 60° C The mixture was cooled to −78° C. heated at 60° C. for 4 h The reaction mixture was filtered the filtrate was evaporated The crude residue was purified by flash chromatography

反応条件: temp:-78.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 1-Benzyl-3-oxo-azetidine (1.6 g, 10 mmol, 1.0 equiv), prepared as described in the literature (Katritzky, A. R.; Cundy, D. J.; J. Heterocyclic Chem. 1994, 31 271-275), was dissolved in dry MeOH and the solution was cooled to −78° C. Gaseous ammonia was was bubbled through the solution for 30 mins at which time 3 angstrom molecular sieves were added and the mixture transferred to a pressure tube. The solution was heated for 30 min at 60° C. The mixture was cooled to −78° C., the tube opened and KCN (0.65 g, 10 mmol, 1.0 equiv) and NH4Cl (0.27 g, 5 mmol, 0.5 equiv) were added and the tube was resealed and heated at 60° C. for 4 h. The reaction mixture was filtered and the filtrate was evaporated. The crude residue was purified by flash chromatography using 2% MeOH in CH2Cl2 to give the desired product (0.11 g, 6%) as a brown oil; MS, m/z 188=M+1. Gaseous ammonia was was bubbled through the solution for 30 mins at which time 3 angstrom molecular sieves were added the mixture transferred to a pressure tube The solution was heated for 30 min at 60° C The mixture was cooled to −78° C. heated at 60° C. for 4 h The reaction mixture was filtered the filtrate was evaporated The crude residue was purified by flash chromatography