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| 中間体 | ethyl 2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[2,3-c]pyrrole-5-carboxylate |
|---|---|
| IUPAC 名 | — |
| CAS番号 | 132414-79-0 |
| データベース ID | 19100952 |
| 分子式 | — |
| 分子量 | — |
製品情報
ethyl 2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[2,3-c]pyrrole-5-carboxylate (CAS 132414-79-0) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
想定用途
専門的研究・工業用途限定
データベース ID 19100952
安全上の注意
For professional research and industrial use only. Review the supplier safety data sheet before handling.
合成データ
12 反応 · 12 文献
反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-b8a584825faa4f5f870bd23dd72a3010反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-b8a584825faa4f5f870bd23dd72a3010反応条件: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 5% palladium hydroxide on activated carbon (13.9 g, 50% w/w in water) was added to a pressure reactor. The product of Example A3 (as 506.8 g of a 25.9 wt % solution of ethyl 1-((R)-1-phenylethyl)hexahydropyrrolo[2,3-c]pyrrole-5(1H)-carboxylate (131.3 g) in MeOH was added, followed by a MeOH rinse (37 g). The mixture was heated to 50° C. under an atmosphere of hydrogen (40 psi) for 4 hours. The mixture was filtered through HYFLO Filter Aid (HYFLO is a registered trademark of Celite Products Company of Los Angeles, Calif.) and rinsed with 200 mL of MeOH to provide a solution containing 78.9 g of the title compound. rinse (37 g) The mixture was filtered through HYFLO Filter Aid (HYFLO ) and rinsed with 200 mL of MeOH to provide a solution
ソース ID: ord-69b989b0f3ba442aa7dc339b3fea448c反応条件: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 5% palladium hydroxide on activated carbon (13.9 g, 50% w/w in water) was added to a pressure reactor. The product of Example A3 (as 506.8 g of a 25.9 wt % solution of ethyl 1-((R)-1-phenylethyl)hexahydropyrrolo[2,3-c]pyrrole-5(1H)-carboxylate (131.3 g) in MeOH was added, followed by a MeOH rinse (37 g). The mixture was heated to 50° C. under an atmosphere of hydrogen (40 psi) for 4 hours. The mixture was filtered through HYFLO Filter Aid (HYFLO is a registered trademark of Celite Products Company of Los Angeles, Calif.) and rinsed with 200 mL of MeOH to provide a solution containing 78.9 g of the title compound. rinse (37 g) The mixture was filtered through HYFLO Filter Aid (HYFLO ) and rinsed with 200 mL of MeOH to provide a solution
ソース ID: ord-69b989b0f3ba442aa7dc339b3fea448c反応条件: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 5% Palladium hydroxide on activated carbon (13.9 g, 50% w/w in water) was added to a pressure reactor. The product of Example A3 (as 506.8 g of a 25.9 wt % solution of ethyl 1-((R)-1-phenylethyl)hexahydropyrrolo[2,3-c]pyrrole-5(1H)-carboxylate (131.3 g) in MeOH) was added, followed by a methanol rinse (37 g). The mixture was heated to 50° C. under an atmosphere of hydrogen (40 psi) for 4 hours. The mixture was filtered through Hyflo® Filter Aid and rinsed with 200 mL of MeOH to provide a solution containing 78.9 g of the title compound. rinse (37 g) The mixture was filtered through Hyflo® Filter Aid rinsed with 200 mL of MeOH to provide a solution
ソース ID: ord-1ffd651d5e484a56ba3b0fcbeba5233b反応条件: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 5% Palladium hydroxide on activated carbon (13.9 g, 50% w/w in water) was added to a pressure reactor. The product of Example A3 (as 506.8 g of a 25.9 wt % solution of ethyl 1-((R)-1-phenylethyl)hexahydropyrrolo[2,3-c]pyrrole-5(1H)-carboxylate (131.3 g) in MeOH) was added, followed by a methanol rinse (37 g). The mixture was heated to 50° C. under an atmosphere of hydrogen (40 psi) for 4 hours. The mixture was filtered through Hyflo® Filter Aid and rinsed with 200 mL of MeOH to provide a solution containing 78.9 g of the title compound. rinse (37 g) The mixture was filtered through Hyflo® Filter Aid rinsed with 200 mL of MeOH to provide a solution
ソース ID: ord-1ffd651d5e484a56ba3b0fcbeba5233b反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 21.2 g (77.3 mmol) of ethyl 2-benzyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate (Example Ae) in 400 ml of ethanol are hydrogenated on 3 g of palladium/active carbon (10% Pd) at 100° C. and 100 bar. The catalyst is filtered off, the filtrate is concentrated, and the residue is distilled. The catalyst is filtered off the filtrate is concentrated the residue is distilled
ソース ID: ord-27f4dff4da604a05ab4932515d2d704c反応条件: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 5% Palladium hydroxide on activated carbon (13.9 g, 50% w/w in water) was added to a pressure reactor. The product of Example A3 (as 506.8 g of a 25.9 wt % solution of ethyl 1-((R)-1-phenylethyl)hexahydropyrrolo[2,3-c]pyrrole-5(1H)-carboxylate (131.3 g) in MeOH) was added, followed by a methanol rinse (37 g). The mixture was heated to 50° C. under an atmosphere of hydrogen (40 psi) for 4 hours. The mixture was filtered through Hyflo® Filter Aid and rinsed with 200 mL of MeOH to provide a solution containing 78.9 g of the title compound. rinse (37 g) The mixture was filtered through Hyflo® Filter Aid rinsed with 200 mL of MeOH to provide a solution
ソース ID: ord-e0b03a46978945589b7d7743c26e18ad反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 21.2 g (77.3 mmol) of ethyl 2-benzyl-2,7-diazabicyclo [3.3.0]octane-7-carboxylate in 400 ml of ethanol are hydrogenated at 100° C. and 100 bar on 3 g of palladium-active carbon (10% Pd). The catalyst is filtered off, the filtrate is concentrated and the residue is distilled. are hydrogenated at 100° C. The catalyst is filtered off the filtrate is concentrated the residue is distilled
ソース ID: ord-87f132614fd449179cd37f86380cbc3f反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 21.2 g (77.3 mmol) of ethyl 2-benzyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate (Example Ae) in 400 ml of ethanol are hydrogenated on 3 g of palladium/active carbon (10% Pd) at 100° C. and 100 bar. The catalyst is filtered off, the filtrate is concentrated, and the residue is distilled. The catalyst is filtered off the filtrate is concentrated the residue is distilled
ソース ID: ord-28273d2cd9944dcaa351f75aecb76743反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 21.2 g (77.3 mmol) of ethyl 2-benzyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate in 400 ml of ethanol are hydrogenated at 100° C. and 100 bar on 3 g of palladium-active carbon (10% Pd). The catalyst is filtered off, the filtrate is concentrated and the residue is distilled. are hydrogenated at 100° C. The catalyst is filtered off the filtrate is concentrated the residue is distilled
ソース ID: ord-7dc23fef01214bb083ee94662063540d反応条件: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 5% palladium hydroxide on activated carbon (13.9 g, 50% w/w in water) was added to a pressure reactor. The product of Example A3 (as 506.8 g of a 25.9 wt % solution of ethyl 1-((R)-1-phenylethyl)hexahydropyrrolo[2,3-c]pyrrole-5(1H)-carboxylate (131.3 g) in MeOH was added, followed by a MeOH rinse (37 g). The mixture was heated to 50° C. under an atmosphere of hydrogen (40 psi) for 4 hours. The mixture was filtered through HYFLO Filter Aid (HYFLO is a registered trademark of Celite Products Company of Los Angeles, Calif.) and rinsed with 200 mL of MeOH to provide a solution containing 78.9 g of the title compound. rinse (37 g) The mixture was filtered through HYFLO Filter Aid (HYFLO ) and rinsed with 200 mL of MeOH to provide a solution
ソース ID: ord-69b989b0f3ba442aa7dc339b3fea448cPubChem References
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