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CC(=O)C1=CC(=C(C(=C1)F)O)F製品情報
1-(3,5-difluoro-4-hydroxyphenyl)ethanone (CAS 133186-55-7) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
想定用途
専門的研究・工業用途限定
データベース ID 15151338
安全上の注意
For professional research and industrial use only. Review the supplier safety data sheet before handling.
合成データ
12 反応 · 12 文献
反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-a75f828170bf4feeb793b1edaed7b0eb反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-aaaf47c76da1468ca2f167ed6f2757c3反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-a75f828170bf4feeb793b1edaed7b0eb反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-a75f828170bf4feeb793b1edaed7b0eb反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 1-(3,5-difluoro-4-hydroxyphenyl)ethanone (8.1 g, 47 mmol), 3-bromo-1-chloropropane (14.7 g, 93 mmol) and K2CO3 (21.3 g, 154 mmol) in acetone (120 mL) was stirred at reflux for 20 h. The reaction was cooled to rt and concentrated at reduced pressure, then partitioned between water and methylene chloride. The aqueous layer was extracted twice with methylene chloride to obtain 1-[4-(3-chloropropoxy)-3,5-difluoro-phenyl]ethanone (12.9 g, quantitative yield); MS m/z 249 (M+H). at reflux for 20 h concentrated at reduced pressure partitioned between water and methylene chloride The aqueous layer was extracted twice with methylene chloride
ソース ID: ord-2ce2e3fb695642519cc47f2420824a23反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 1-(3,5-difluoro-4-methoxyphenyl)ethanone (12 g, 64.5 mmol) and 48% aqueous HBr (32 mL) was stirred at reflux for 30 h. The reaction was cooled to rt and diluted with water and the aqueous layer was extracted twice with methylene chloride. The combined organics were dried (Na2SO4), filtered, and concentrated to give 1-(3,5-difluoro-4-hydroxyphenyl)ethanone (10 g, 91%), mp 141-143° C.; MS m/z 171 (M−H). at reflux for 30 h the aqueous layer was extracted twice with methylene chloride The combined organics were dried (Na2SO4) filtered concentrated
ソース ID: ord-ebba247cacdc419cac68509994e37e2e反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 1-(3,5-difluoro-4-methoxyphenyl)ethanone (12 g, 64.5 mmol) and 48% aqueous HBr (32 mL) was stirred at reflux for 30 h. The reaction was cooled to rt and diluted with water and the aqueous layer was extracted twice with methylene chloride. The combined organics were dried (Na2SO4), filtered, and concentrated to give 1-(3,5-difluoro-4-hydroxyphenyl)ethanone (10 g, 91%), mp 141-143° C.; MS m/z 171 (M−H). at reflux for 30 h the aqueous layer was extracted twice with methylene chloride The combined organics were dried (Na2SO4) filtered concentrated
ソース ID: ord-ebba247cacdc419cac68509994e37e2e反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 1-(3,5-difluoro-4-hydroxyphenyl)ethanone (8.1 g, 47 mmol), 3-bromo-1-chloropropane (14.7 g, 93 mmol) and K2CO3 (21.3 g, 154 mmol) in acetone (120 mL) was stirred at reflux for 20 h. The reaction was cooled to rt and concentrated at reduced pressure, then partitioned between water and methylene chloride. The aqueous layer was extracted twice with methylene chloride to obtain 1-[4-(3-chloropropoxy)-3,5-difluoro-phenyl]ethanone (12.9 g, quantitative yield); MS m/z 249 (M+H). at reflux for 20 h concentrated at reduced pressure partitioned between water and methylene chloride The aqueous layer was extracted twice with methylene chloride
ソース ID: ord-1d695e6d9d7e441686033432e88c81e7反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 1-(3,5-difluoro-4-methoxyphenyl)ethanone (12 g, 64.5 mmol) and 48% aqueous HBr (32 mL) was stirred at reflux for 30 h. The reaction was cooled to rt and diluted with water and the aqueous layer was extracted twice with methylene chloride. The combined organics were dried (Na2SO4), filtered, and concentrated to give 1-(3,5-difluoro-4-hydroxyphenyl)ethanone (10 g, 91%), mp 141-143° C.; MS m/z 171 (M−H). at reflux for 30 h the aqueous layer was extracted twice with methylene chloride The combined organics were dried (Na2SO4) filtered concentrated
ソース ID: ord-b7f24d533f3446208c74a6c4dcfea0bb反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 1-(3,5-difluoro-4-hydroxyphenyl)ethanone (8.1 g, 47 mmol), 3-bromo-1-chloropropane (14.7 g, 93 mmol) and K2CO3 (21.3 g, 154 mmol) in acetone (120 mL) was stirred at reflux for 20 h. The reaction was cooled to rt and concentrated at reduced pressure, then partitioned between water and methylene chloride. The aqueous layer was extracted twice with methylene chloride to obtain 1-[4-(3-chloropropoxy)-3,5-difluoro-phenyl]ethanone (12.9 g, quantitative yield); MS m/z 249 (M+H). at reflux for 20 h concentrated at reduced pressure partitioned between water and methylene chloride The aqueous layer was extracted twice with methylene chloride
ソース ID: ord-1d695e6d9d7e441686033432e88c81e7反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 1-(3,5-difluoro-4-methoxyphenyl)ethanone (12 g, 64.5 mmol) and 48% aqueous HBr (32 mL) was stirred at reflux for 30 h. The reaction was cooled to rt and diluted with water and the aqueous layer was extracted twice with methylene chloride. The combined organics were dried (Na2SO4), filtered, and concentrated to give 1-(3,5-difluoro-4-hydroxyphenyl)ethanone (10 g, 91%), mp 141-143° C.; MS m/z 171 (M−H). at reflux for 30 h the aqueous layer was extracted twice with methylene chloride The combined organics were dried (Na2SO4) filtered concentrated
ソース ID: ord-b7f24d533f3446208c74a6c4dcfea0bb反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-aaaf47c76da1468ca2f167ed6f2757c3PubChem References
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