N-ethyl-4-oxocyclohexane-1-carboxamide

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Reaction of N-ethyl-4-oxocyclohexanecarboxamide with N-(azetidin-3-yl)-2-((6-(trifluoromethyl)quinazolin-4-yl)amino)acetamide (as prepared in Example 1 Step G) in the presence of TEA and NaBH(OAc)3 as described in Example 1, Step H afforded the product. 1H NMR (DMSO-d6) δ: 0.97 (t, J=7.20 Hz, 3 H) 1.25 (d, J=16.93 Hz, 5 H) 1.48 (br. s., 2 H) 1.67 (br. s., 2 H) 1.97-2.08 (m, 1 H) 2.17 (br. s., 1 H) 2.74 (t, J=7.07 Hz, 2 H) 3.01 (m, J=7.07, 5.81 Hz, 2 H) 3.43 (t, J=7.20 Hz, 2 H) 4.12 (d, J=5.56 Hz, 2 H) 4.17-4.30 (m, 1 H) 7.61 (t, J=5.56 Hz, 1 H) 7.88 (d, J=8.59 Hz, 1 H) 8.05 (dd, J=8.97, 1.39 Hz, 1 H) 8.44 (d, J=7.33 Hz, 1 H) 8.55 (s, 1 H) 8.81 (s, 1 H) 9.05 (t, J=5.43 Hz, 1 H); ESI-MS (m/z): Calcd. For C23H29F3N6O2: 478.23. found: 479 (M+H). afforded the product