[(2S)-1-benzylpiperidin-2-yl]methanamine

反応条件: temp:-78.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a solution of 230 mL (0.23 mmol) of 1M lithium aluminum hydride in THF was added over 20 min a solution of (S)-N-benzylpiperidine-2-carboxamide in 150 mL of THF. The mixture was refluxed for 5 h, diluted with 500 ml of THF, cooled to -78° C. and quenched with a solution of 48 mL 1N aqueous sodium hydroxide in 200 mL THF. The resulting slurry was filtered through a Celite® pad and concentrated at reduced pressure to yield (S)-N-benzyl-2-aminomethylpiperidine (10.9 g, 89%). The mixture was refluxed for 5 h quenched with a solution of 48 mL 1N aqueous sodium hydroxide in 200 mL THF The resulting slurry was filtered through a Celite® pad concentrated at reduced pressure