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C1=CC=C2C=C(C=CC2=C1)NC(=O)NCCCl製品情報
1-(2-chloroethyl)-3-naphthalen-2-ylurea (CAS 13908-57-1) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
想定用途
専門的研究・工業用途限定
データベース ID 256650
安全上の注意
For professional research and industrial use only. Review the supplier safety data sheet before handling.
合成データ
10 反応 · 10 文献
反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-8e4eb8bf9e7f4bc28378c3f5f346aeb7反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-403ea633972e4c878078e0ffdc690e08反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-8e4eb8bf9e7f4bc28378c3f5f346aeb7反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-8e4eb8bf9e7f4bc28378c3f5f346aeb7反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-403ea633972e4c878078e0ffdc690e08反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 1-(2-Chloro-ethyl)-3-naphthalen-2-yl-urea (I-79a: 750 mg, 3.01 mmol) in dry DMF (10 mL) was added to a stirred solution of sodium hydride (150 mg, 3.1 mmol) in THF (10 mL) at 0° C. The reaction temperature was maintained at room temperature for 30 minutes. The reaction was monitored by TLC (5% MeOH in chloroform, double run). The reaction mixture was quenched with MeOH at 0° C., concentrated under reduced pressure and partitioned between ice water and chloroform. The organic layer was dried over Na2SO4, and concentrated under reduced pressure to afford 600 mg (94% yield) of 1-naphthalen-2-yl-imidazolidin-2-one. The reaction mixture was quenched with MeOH at 0° C. concentrated under reduced pressure partitioned between ice water and chloroform The organic layer was dried over Na2SO4 concentrated under reduced pressure
ソース ID: ord-147c786f8e224fc7a174188866e20021反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 1-(2-Chloro-ethyl)-3-naphthalen-2-yl-urea (I-79a: 750 mg, 3.01 mmol) in dry DMF (10 mL) was added to a stirred solution of sodium hydride (150 mg, 3.1 mmol) in THF (10 mL) at 0° C. The reaction temperature was maintained at room temperature for 30 minutes. The reaction was monitored by TLC (5% MeOH in chloroform, double run). The reaction mixture was quenched with MeOH at 0° C., concentrated under reduced pressure and partitioned between ice water and chloroform. The organic layer was dried over Na2SO4, and concentrated under reduced pressure to afford 600 mg (94% yield) of 1-naphthalen-2-yl-imidazolidin-2-one. The reaction mixture was quenched with MeOH at 0° C. concentrated under reduced pressure partitioned between ice water and chloroform The organic layer was dried over Na2SO4 concentrated under reduced pressure
ソース ID: ord-147c786f8e224fc7a174188866e20021反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 1-Chloro-2-isocyanato-ethane (0.81 mL, 9.42 mmol) was added dropwise to a stirred solution of naphthalen-2-ylamine (900 mg, 6.28 mmol) in toluene (50 mL) over a period of 30 minutes at 0° C. The reaction temperature was maintained at room temperature for 5 hours. The reaction was monitored by TLC (5% MeOH in chloroform). The reaction mixture was filtered, washed with toluene and dried under reduced pressure to afford 1.3 g (83% yield) of 1-(2-chloro-ethyl)-3-naphthalen-2-yl-urea. The reaction mixture was filtered washed with toluene dried under reduced pressure
ソース ID: ord-c8861bd504b842b59b45f82cd2b78fd7反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 1-(2-Chloro-ethyl)-3-naphthalen-2-yl-urea (I-79a: 750 mg, 3.01 mmol) in dry DMF (10 mL) was added to a stirred solution of sodium hydride (150 mg, 3.1 mmol) in THF (10 mL) at 0° C. The reaction temperature was maintained at room temperature for 30 minutes. The reaction was monitored by TLC (5% MeOH in chloroform, double run). The reaction mixture was quenched with MeOH at 0° C., concentrated under reduced pressure and partitioned between ice water and chloroform. The organic layer was dried over Na2SO4, and concentrated under reduced pressure to afford 600 mg (94% yield) of 1-naphthalen-2-yl-imidazolidin-2-one. The reaction mixture was quenched with MeOH at 0° C. concentrated under reduced pressure partitioned between ice water and chloroform The organic layer was dried over Na2SO4 concentrated under reduced pressure
ソース ID: ord-471987455f0b4079954e149a9a3aefba反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 1-Chloro-2-isocyanato-ethane (0.81 mL, 9.42 mmol) was added dropwise to a stirred solution of naphthalen-2-ylamine (900 mg, 6.28 mmol) in toluene (50 mL) over a period of 30 minutes at 0° C. The reaction temperature was maintained at room temperature for 5 hours. The reaction was monitored by TLC (5% MeOH in chloroform). The reaction mixture was filtered, washed with toluene and dried under reduced pressure to afford 1.3 g (83% yield) of 1-(2-chloro-ethyl)-3-naphthalen-2-yl-urea. The reaction mixture was filtered washed with toluene dried under reduced pressure
ソース ID: ord-7d1e7ba22c45424894f9727198bc3033PubChem References
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