ethyl 4-(hydroxymethyl)piperidine-4-carboxylate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A solution of hydrochloric acid (12N, 2.5 mL) in dioxane (4.5 mL) is added to 4-hydroxymethylpiperidine-1,4-dicarboxylic acid-1-tert-butyl ester-4-ethyl ester (1.35 g, 0.0047 mol) and stirred at room temperature for 30 minutes. The reaction mixture is concentrated under reduced pressure and the residue is treated with aqueous solution of sodium bicarbonate to adjust the pH to 8-9. It is again concentrated under reduced pressure and the residue is treated with dichloromethane. After drying over sodium sulfate solvent is removed to get 4-hydroxymethylpiperidine-4-carboxylic acid ethyl ester. The reaction mixture is concentrated under reduced pressure the residue is treated with aqueous solution of sodium bicarbonate It is again concentrated under reduced pressure the residue is treated with dichloromethane After drying over sodium sulfate solvent is removed