trimethyl(1,2,2-trifluoroethenyl)silane

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Chlorotrifluoroethylene of the formula (10) is treated with n-butyl lithium and then reacted with chlorotrimethylsilane of the formula (11) to obtain 1,1,2-trifluoro-2-trimethylsilylethylene of the formula (12). Then, without isolation, this compound (12) is reacted further with a lithium compound of the formula (13) to obtain a difluoroethylene compound of the formula (14).

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Chlorotrifluoroethylene of the formula (7) is treated with n-butyl lithium and then reacted with chlorotrimethylsilane of the formula (8) to obtain 1,1,2-trifluoro-2-trimethylsilylethylene of the formula (9). Then, without isolation, this compound (9) is reacted further with a lithium compound of the formula (10) to obtain a difluoroethylene compound of the formula (11).

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Chlorotrifluoroethylene of the formula (10) is treated with n-butyl lithium and then reacted with chlorotrimethylsilane of the formula (11) to obtain 1,1,2-trifluoro-2-trimethylsilylethylene of the formula (12). Then, without isolation, this compound (12) is reacted further with a lithium compound of the formula (13) to obtain a difluoroethylene compound of the formula (14).

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Chlorotrifluoroethylene of the formula (10) is treated with n-butyl lithium and then reacted with chlorotrimethylsilane of the formula (11) to obtain 1,1,2-trifluoro-2-trimethylsilylethylene of the formula (12). Then, without isolation, this compound (12) is reacted further with a lithium compound of the formula (13) to obtain a difluoroethylene compound of the formula (14).

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: In the reaction with 1,1,2-trifluoro-2-trimethylsilyl ethylene analogously to instructions 1.1, 60 mg of aldehyde 9a yields 77 mg of trimethylsilyl ether 23a as a colorless foam (GC-MS: m/z theor.: 664, pract.: 664) and a mixture of its diastereomers. The latter is used without further purification in the next stage.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: In the reaction with 1,1,2-trifluoro-2-trimethylsilyl ethylene analogously to instructions 1.1, 60 mg of aldehyde 9a yields 77 mg of trimethylsilyl ether 23a as a colorless foam (GC-MS: m/z theor.: 664, pract.: 664) and a mixture of its diastereomers. The latter is used without further purification in the next stage.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Chlorotrifluoroethylene of the formula (7) is treated with n-butyl lithium and then reacted with chlorotrimethylsilane of the-formula (8) to obtain 1,1,2-trifluoro-2-trimethylsilylethylene of the formula (9). Then, without isolation, this compound (9) is reacted further with a lithium compound of the formula (10) to obtain a difluoroethylene compound of the formula (11).

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Chlorotrifluoroethylene of the formula (7) is treated with n-butyl lithium and then reacted with chlorotrimethylsilane of the formula (8) to obtain 1,1,2-trifluoro-2-trimethylsilylethylene of the formula (9). Then, without isolation, this compound (9) is reacted further with a lithium compound of the formula (10) to obtain a difluoroethylene compound of the formula (11).

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Chlorotrifluoroethylene of the formula (7) is treated with n-butyl lithium and then reacted with chlorotrimethylsilane of the formula (8) to obtain 1,1,2-trifluoro-2-trimethylsilylethylene of the formula (9). Then, without isolation, this compound (9) is reacted further with a lithium compound of the formula (10) to obtain a difluoroethylene compound of the formula (11).