Stearic acid-N-hydroxysuccinimide ester

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 1.87 g of stearic acid was dissolved in 50 ml of dichloromethane, to which 0.76 g of N-hydroxysuccinimide and 1.25 g of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride were added and stirred at room temperature for 24 hours. After the reaction, the solution was combined with 100 ml of water and subjected to liquid-liquid separation using a separatory funnel. The organic phase obtained was dehydrated with magnesium sulfate, and enriched using an evaporator. The enriched solution was added dropwise to 20 volumes of ethanol to form a white precipitate, which was collected by filtration and dried under reduced pressure to obtain N-succinimidyl stearate. were added After the reaction subjected to liquid-liquid separation The organic phase obtained an evaporator The enriched solution was added dropwise to 20 volumes of ethanol to form a white precipitate, which was collected by filtration dried under reduced pressure

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The title compound was prepared similarly as shown in example 3 from L-lysine monohydrochloride (0.94 g, 5.1 mmol) and succinimidyl stearate (1.94 g, 5.1 mmol) in the presence of triethylamine (2.15 ml, 15.3 mmol) in 9.4 ml of water and 9.4 ml of acetone. The product was washed with cold water and ethanol and then dried yielding 1.98 g (92.7%) of the title compound. Infrared: 1580-1590 cm-1 (ionized carboxyl group), 1635 and 1520-1535 cm-1 (amide bands). The title compound was prepared similarly The product was washed with cold water and ethanol dried