heptadecan-1-ol

反応条件: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 1-Heptadecanol (10 g, 39.1 mmol) was placed in a dry 25 ml round bottom flask attached to a reflux condenser and heated to 60° C. under a nitrogen atmosphere. Phosphorous tribromide (10 g, 39.1 mmol) was added dropwise and the resulting solution was stirred for 48 h. The reaction mixture was then cooled in an ice bath and quenched with a saturated solution of NaHCO3 (10 ml). The aqueous layer was extracted with ether (4×10 ml). The combined organic layers were dried over MgSO4, filtered and concentrated. The crude residue was flash chromatographed (hexanes) to afford 7.2 g (57%) of 1-bromoheptadecane as a colorless oil. attached to a reflux condenser The reaction mixture was then cooled in an ice bath quenched with a saturated solution of NaHCO3 (10 ml) The aqueous layer was extracted with ether (4×10 ml) The combined organic layers were dried over MgSO4 filtered concentrated chromatographed (hexanes)

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 1-octadecanol; 2-methyl-1-undecanol; 2-propyl-1-nonanol;

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of 256 parts of heptadecyl alcohol, 60 parts of urea and 5 parts of a cation exchanger which is commercially available under the registered name Amberlite 200 and, having been treated in accordance with Example 1, contains nickel, is heated in a stirred vessel to 140°-145° C., whilst stirring. After filtering off the exchanger whilst the reaction solution is hot, 280 parts of heptadecyl carbamate are obtained. This corresponds to a yield of 94% of theory. The product has a melting point of 53°-54° C. having been treated in accordance with Example 1 is heated in a stirred vessel to 140°-145° C. After filtering off the exchanger whilst the reaction solution

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of 256 parts of heptadecyl alcohol, 60 parts of urea and 5 parts of a cation exchanger which is commercially available under the registered name Amberlite 200 and, having been treated in accordance with Example 1, contains nickel, is heated in a stirred vessel to 140°-145° C., whilst stirring. After filtering off the exchanger whilst the reaction solution is hot, 280 parts of heptadecyl carbamate are obtained. This corresponds to a yield of 94% of theory. The product has a melting point of 53°-54° C. having been treated in accordance with Example 1 is heated in a stirred vessel to 140°-145° C. After filtering off the exchanger whilst the reaction solution

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of 2-nitro-4-carboxyaniline (0.52 g), heptadecanol (0.7 g) and dimethylaminopyridine (20 mg) in dichloromethane (20 ml) was prepared and dicyclohexyldicarbodiimide (0.62 g) was added. The mixture was stirred for 48 hours and filtered. After separating between chloroform and 3% caustic soda solution the organic phase was washed with water, dried with magnesium sulphate and the solvent removed to leave a yellow solid. The solid was purified by chromatography to give a yellow solid which was recrystallised from 50:50 chloroform-hexane (yield: 0.85 g, m.p. 103°-105° C.). was prepared filtered After separating between chloroform and 3% caustic soda solution the organic phase was washed with water dried with magnesium sulphate the solvent removed to leave a yellow solid The solid was purified by chromatography to give a yellow solid which was recrystallised from 50:50 chloroform-hexane (yield: 0.85 g, m.p. 103°-105° C.)

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of 4-carboxy-2-nitroaniline (0.52g), heptadecanol (0.7 g) and dimethylaminopyridine (20 mg) in dichloromethane (20 ml) was prepared and dicyclohexyldicarbodiimide (0.62 g) was added. The mixture was stirred for 48 hours and filtered. After separating between chloroform and 3% caustic soda solution the organic phase was washed with water, dried with magnesium sulphate and the solvent removed to leave a yellow solid. The solid was purified by chromatography to give a yellow solid which was recrystallised from 50:50 chloroform-hexane (yield: 0.85 g, m.p. 103°-105° C). was prepared filtered After separating between chloroform and 3% caustic soda solution the organic phase was washed with water dried with magnesium sulphate the solvent removed to leave a yellow solid The solid was purified by chromatography to give a yellow solid which was recrystallised from 50:50 chloroform-hexane (yield: 0.85 g, m.p. 103°-105° C)

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of 4-carboxy-2-nitroaniline (0.52g), heptadecanol (0.7 g) and dimethylaminopyridine (20 mg) in dichloromethane (20 ml) was prepared and dicyclohexyldicarbodiimide (0.62 g) was added. The mixture was stirred for 48 hours and filtered. After separating between chloroform and 3% caustic soda solution the organic phase was washed with water, dried with magnesium sulphate and the solvent removed to leave a yellow solid. The solid was purified by chromatography to give a yellow solid which was recrystallised from 50:50 chloroform-hexane (yield: 0.85 g, m.p. 103°-105° C). was prepared filtered After separating between chloroform and 3% caustic soda solution the organic phase was washed with water dried with magnesium sulphate the solvent removed to leave a yellow solid The solid was purified by chromatography to give a yellow solid which was recrystallised from 50:50 chloroform-hexane (yield: 0.85 g, m.p. 103°-105° C)

反応条件: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 1-Heptadecanol (10 g, 39.1 mmol) was placed in a dry 25 ml round bottom flask attached to a reflux condenser and heated to 60° C. under a nitrogen atmosphere. Phosphorous tribromide (10 g, 39.1 mmol) was added dropwise and the resulting solution was stirred for 48 h. The reaction mixture was then cooled in an ice bath and quenched with a saturated solution of NaHCO3 (10 ml). The aqueous layer was extracted with ether (4×10 ml). The combined organic layers were dried over MgSO4, filtered and concentrated. The crude residue was flash chromatographed (hexanes) to afford 7.2 g (57%) of 1-bromoheptadecane as a colorless oil. attached to a reflux condenser The reaction mixture was then cooled in an ice bath quenched with a saturated solution of NaHCO3 (10 ml) The aqueous layer was extracted with ether (4×10 ml) The combined organic layers were dried over MgSO4 filtered concentrated chromatographed (hexanes)

反応条件: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 1-Heptadecanol (10 g, 39.1 mmol) was placed in a dry 25 ml round bottom flask attached to a reflux condenser and heated to 60° C. under a nitrogen atmosphere. Phosphorous tribromide (10 g, 39.1 mmol) was added dropwise and the resulting solution was stirred for 48 h. The reaction mixture was then cooled in an ice bath and quenched with a saturated solution of NaHCO3 (10 ml). The aqueous layer was extracted with ether (4×10 ml). The combined organic layers were dried over MgSO4, filtered and concentrated. The crude residue was flash chromatographed (hexanes) to afford 7.2 g (57%) of 1-bromoheptadecane as a colorless oil. attached to a reflux condenser The reaction mixture was then cooled in an ice bath quenched with a saturated solution of NaHCO3 (10 ml) The aqueous layer was extracted with ether (4×10 ml) The combined organic layers were dried over MgSO4 filtered concentrated chromatographed (hexanes)

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 1-octadecanol; 2-methyl-1-undecanol; 2-propyl-1-nonanol;

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 1-octadecanol; 2-methyl-1-undecanol; 2-propyl-1-nonanol;

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of 256 parts of heptadecyl alcohol, 60 parts of urea and 5 parts of a cation exchanger which is commercially available under the registered name Amberlite 200 and, having been treated in accordance with Example 1, contains nickel, is heated in a stirred vessel to 140°-145° C., whilst stirring. After filtering off the exchanger whilst the reaction solution is hot, 280 parts of heptadecyl carbamate are obtained. This corresponds to a yield of 94% of theory. The product has a melting point of 53°-54° C. having been treated in accordance with Example 1 is heated in a stirred vessel to 140°-145° C. After filtering off the exchanger whilst the reaction solution