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COC1=C(C=CC(=C1)C=O)OCCCCl製品情報
4-(3-chloropropoxy)-3-methoxybenzaldehyde (CAS 151719-92-5) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
想定用途
専門的研究・工業用途限定
データベース ID 4610841
安全上の注意
For professional research and industrial use only. Review the supplier safety data sheet before handling.
合成データ
12 反応 · 12 文献
反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-52ee253ab6b546379f1d0a28acbc9d71反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-432d825184c742cca85920bb0e5eb063反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of vanillin (30.4 g, 200 mmol), K2CO3 (27.6 g) and acetone (150 ml) was stirred and refluxed for 0.5 hours. Heating was removed and 1-bromo-3-chloropropane (40.8 g, 260 mmol) in acetone was added dropwise. The reaction was stirred and refluxed for 16 hours, and then it was poured into water. The aqueous mixture was extracted with diethyl ether, the extract was dried (MgSO4), and the solution was concentrated to afford an oil, which upon evacuation solidified to a white solid (50.2 g). An 8.0 g sample was flash chromatographed on silica gel with 50% ethyl acetatehexane as eluent. Concentration of appropriate fractions gave 2.7 g (37%) of 4-(3-chloropropoxy)-3-methoxybenzaldehyde as a white solid, m.p.=53-55° C. refluxed for 0.5 hours Heating was removed The reaction was stirred refluxed for 16 hours The aqueous mixture was extracted with diethyl ether the extract was dried (MgSO4) the solution was concentrated to afford an oil, which upon evacuation chromatographed on silica gel with 50% ethyl acetatehexane as eluent
ソース ID: ord-48d6b593492d47a8b248ff8b46fa29e0反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of vanillin (30.4 g, 200 mmol), K2CO3 (27.6 g) and acetone (150 ml) was stirred and refluxed for 0.5 hours. Heating was removed and 1-bromo-3-chloropropane (40.8 g, 260 mmol) in acetone was added dropwise. The reaction was stirred and refluxed for 16 hours, and then it was poured into water. The aqueous mixture was extracted with diethyl ether, the extract was dried (MgSO4), and the solution was concentrated to afford an oil, which upon evacuation solidified to a white solid (50.2 g). An 8.0 g sample was flash chromatographed on silica gel with 50% ethyl acetatehexane as eluent. Concentration of appropriate fractions gave 2.7 g (37%) of 4-(3chloropropoxy)-3-methoxybenzaldehyde as a white solid, m.p.=53°-55° C. refluxed for 0.5 hours Heating was removed The reaction was stirred refluxed for 16 hours The aqueous mixture was extracted with diethyl ether the extract was dried (MgSO4) the solution was concentrated to afford an oil, which upon evacuation chromatographed on silica gel with 50% ethyl acetatehexane as eluent
ソース ID: ord-518510d2c72e4a45a8e7cf9b5ec4c8d1反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of vanillin (30.4 g, 200 mmol), K2CO3 (27.6 g) and acetone (150 ml) was stirred and refluxed for 0.5 hours. Heating was removed and 1-bromo-3-chloropropane (40.8 g, 260 mmol) in acetone was added dropwise. The reaction was stirred and refluxed for 16 hours, and then it was poured into water. The aqueous mixture was extracted with diethyl ether, the extract was dried (MgSO4), and the solution was concentrated to afford an oil, which upon evacuation solidified to a white solid (50.2 g). An 8.0 g sample was flash chromatographed on silica gel with 50% ethyl acetatehexane as eluent. Concentration of appropriate fractions gave 2.7 g (37%) of 4-(3chloropropoxy)-3-methoxybenzaldehyde as a white solid, m.p.=53°-55° C. refluxed for 0.5 hours Heating was removed The reaction was stirred refluxed for 16 hours The aqueous mixture was extracted with diethyl ether the extract was dried (MgSO4) the solution was concentrated to afford an oil, which upon evacuation chromatographed on silica gel with 50% ethyl acetatehexane as eluent
ソース ID: ord-a37c73ce239e42eaa66e359c4270030d反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of vanillin (30.4 g, 200 mmol), K2CO3 (27.6 g) and acetone (150 ml) was stirred and refluxed for 0.5 hours. Heating was removed and 1-bromo-3-chloropropane (40.8 g, 260 mmol) in acetone was added dropwise. The reaction was stirred and refluxed for 16 hours, and then it was poured into water. The aqueous mixture was extracted with diethyl ether, the extract was dried (MgSO4), and the solution was concentrated to afford an oil, which upon evacuation solidified to a white solid (50.2 g). An 8.0 g sample was flash chromatographed on silica gel with 50% ethyl acetatehexane as eluent. Concentration of appropriate fractions gave 2.7 g (37%) of 4-(3-chloropropoxy)-3-methoxybenzaldehyde as a white solid, m.p.=53°-55° C. refluxed for 0.5 hours Heating was removed The reaction was stirred refluxed for 16 hours The aqueous mixture was extracted with diethyl ether the extract was dried (MgSO4) the solution was concentrated to afford an oil, which upon evacuation chromatographed on silica gel with 50% ethyl acetatehexane as eluent
ソース ID: ord-569799968fdd4c9a980184c1b4d8cbc2反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of vanillin (30.4 g, 200 mmol), K2CO3 (27.6 g) and acetone (150 ml) was stirred and refluxed for 0.5 hours. Heating was removed and 1-bromo-3-chloropropane (40.8 g, 260 mmol) in acetone was added dropwise. The reaction was stirred and refluxed for 16 hours, and then it was poured into water. The aqueous mixture was extracted with diethyl ether, the extract was dried (MgSO4), and the solution was concentrated to afford an oil, which upon evacuation solidified to a white solid (50.2 g). An 8.0 g sample was flash chromatographed on silica gel with 50% ethyl acetatehexane as eluent. Concentration of appropriate fractions gave 2.7 g (37%) of 4-(3-chloropropoxy)-3-methoxybenzaldehyde as a white solid, m.p.=53°-55° C. refluxed for 0.5 hours Heating was removed The reaction was stirred refluxed for 16 hours The aqueous mixture was extracted with diethyl ether the extract was dried (MgSO4) the solution was concentrated to afford an oil, which upon evacuation chromatographed on silica gel with 50% ethyl acetatehexane as eluent
ソース ID: ord-569799968fdd4c9a980184c1b4d8cbc2反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of vanillin (30.4 g, 200 mmol), K2CO3 (27.6 g) and acetone (150 ml) was stirred and refluxed for 0.5 hours. Heating was removed and 1-bromo-3-chloropropane (40.8 g, 260 mmol) in acetone was added dropwise. The reaction was stirred and refluxed for 16 hours, and then it was poured into water. The aqueous mixture was extracted with diethyl ether, the extract was dried (MgSO4), and the solution was concentrated to afford an oil, which upon evacuation solidified to a white solid (50.2 g). An 8.0 g sample was flash chromatographed on silica gel with 50% ethyl acetatehexane as eluent. Concentration of appropriate fractions gave 2.7 g (37%) of 4-(3-chloropropoxy)-3-methoxybenzaldehyde as a white solid, m.p.=53°-55° C. refluxed for 0.5 hours Heating was removed The reaction was stirred refluxed for 16 hours The aqueous mixture was extracted with diethyl ether the extract was dried (MgSO4) the solution was concentrated to afford an oil, which upon evacuation chromatographed on silica gel with 50% ethyl acetatehexane as eluent
ソース ID: ord-7cd5c177ba2c4214bd45e0f4004b1e7c反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of vanillin (30.4 g, 200 mmol), K2CO3 (27.6 g) and acetone (150 ml) was stirred and refluxed for 0.5 hours. Heating was removed and 1-bromo-3-chloropropane (40.8 g, 260 mmol) in acetone was added dropwise. The reaction was stirred and refluxed for 16 hours, and then it was poured into water. The aqueous mixture was extracted with diethyl ether, the extract was dried (MgSO4), and the solution was concentrated to afford an oil, which upon evacuation solidified to a white solid (50.2 g). An 8.0 g sample was flash chromatographed on silica gel with 50% ethyl acetatehexane as eluent. Concentration of appropriate fractions gave 2.7 g (37%) of 4-(3-chloropropoxy)-3-methoxybenzaldehyde as a white solid, m.p.=53°-55° C. refluxed for 0.5 hours Heating was removed The reaction was stirred refluxed for 16 hours The aqueous mixture was extracted with diethyl ether the extract was dried (MgSO4) the solution was concentrated to afford an oil, which upon evacuation chromatographed on silica gel with 50% ethyl acetatehexane as eluent
ソース ID: ord-7cd5c177ba2c4214bd45e0f4004b1e7c反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of vanillin (30.4 g, 200 mmol), K2CO3 (27.6 g) and acetone (150 ml) was stirred and refluxed for 0.5 hours. Heating was removed and 1-bromo-3-chloropropane (40.8 g, 260 mmol) in acetone was added dropwise. The reaction was stirred and refluxed for 16 hours, and then it was poured into water. The aqueous mixture was extracted with diethyl ether, the extract was dried (MgSO4), and the solution was concentrated to afford an oil, which upon evacuation solidified to a white solid (50.2 g). An 8.0 g sample was flash chromatographed on silica gel with 50% ethyl acetatehexane as eluent. Concentration of appropriate fractions gave 2.7 g (37%) of 4-(3-chloropropoxy)-3-methoxybenzaldehyde as a white solid, m.p.=53°-55° C. refluxed for 0.5 hours Heating was removed The reaction was stirred refluxed for 16 hours The aqueous mixture was extracted with diethyl ether the extract was dried (MgSO4) the solution was concentrated to afford an oil, which upon evacuation chromatographed on silica gel with 50% ethyl acetatehexane as eluent
ソース ID: ord-0f64425c85714406947be9219e97a1fe反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of vanillin (30.4 g, 200 mmol), K2CO3 (27.6 g) and acetone (150 ml) was stirred and refluxed for 0.5 hours. Heating was removed and 1-bromo-3-chloropropane (40.8 g, 260 mmol) in acetone was added dropwise. The reaction was stirred and refluxed for 16 hours, and then it was poured into water. The aqueous mixture was extracted with diethyl ether, the extract was dried (MgSO4), and the solution was concentrated to afford an oil, which upon evacuation solidified to a white solid (50.2 g). An 8.0 g sample was flash chromatographed on silica gel with 50% ethyl acetatehexane as eluent. Concentration of appropriate fractions gave 2.7 g (37%) of 4-(3-chloropropoxy)-3-methoxybenzaldehyde as a white solid, m.p.=53°-55° C. refluxed for 0.5 hours Heating was removed The reaction was stirred refluxed for 16 hours The aqueous mixture was extracted with diethyl ether the extract was dried (MgSO4) the solution was concentrated to afford an oil, which upon evacuation chromatographed on silica gel with 50% ethyl acetatehexane as eluent
ソース ID: ord-0f64425c85714406947be9219e97a1fe反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of vanillin (30.4 g, 200 mmol), K2CO3 (27.6 g) and acetone (150 ml) was stirred and refluxed for 0.5 hours. Heating was removed and 1-bromo-3-chloropropane (40.8 g, 260 mmol) in acetone was added dropwise. The reaction was stirred and refluxed for 16 hours, and then it was poured into water. The aqueous mixture was extracted with diethyl ether, the extract was dried (MgSO4), and the solution was concentrated to afford an oil, which upon evacuation solidified to a white solid (50.2 g). An 8.0 g sample was flash chromatographed on silica gel with 50% ethyl acetatehexane as eluent. Concentration of appropriate fractions gave 2.7 g (37%) of 4-(3-chloropropoxy)-3-methoxybenzaldehyde as a white solid, m.p.=53°-55° C. refluxed for 0.5 hours Heating was removed The reaction was stirred refluxed for 16 hours The aqueous mixture was extracted with diethyl ether the extract was dried (MgSO4) the solution was concentrated to afford an oil, which upon evacuation chromatographed on silica gel with 50% ethyl acetatehexane as eluent
ソース ID: ord-241133132f954945ad2728be35fce819PubChem References
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