tert-butyl 2-(methylsulfonyl)ethylcarbamate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: In a dried reaction flask, tert-butyl 2-(methylsulfonyl)ethylcarbamate (0.906 g, 4.06 mmol) was dissolved in dichloromethane (60 mL). Trifluoroacetic acid (27.8 mL) was added dropwise at −10° C. The mixture was stirred for 1.5 hr, and was concentrated at reduced pressure to produce a crude brown oil (1.258 g). was concentrated at reduced pressure

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: In a dried reaction flask, the crude tert-butyl 2-(methylthio)ethylcarbamate (2.464 g, about 11.0 mmol) was dissolved in tetrahydrofuran (22 mL). To the mixture was added 77% mCPBA (5.698 g, 25.42 mmol) in portion at 0° C. The mixture was stirred for 1 hr. Water, saturated aqueous sodium bicarbonate solution and ethyl acetate were added. The mixture was extracted with ethyl acetate. The combined organic phase was washed with saturated salt water, dried over anhydrous sodium sulfate, and was purified by silica gel column chromatography with ethyl acetate to obtain a white solid (0.95 g) in 38.7% yield. In a dried reaction flask The mixture was extracted with ethyl acetate The combined organic phase was washed with saturated salt water dried over anhydrous sodium sulfate was purified by silica gel column chromatography with ethyl acetate