N-[(1R)-2,3-dihydro-1H-inden-1-yl]-2,2,2-trifluoroacetamide

反応条件: temp:22.51; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a suspension of AlCl3 (89.2 g, 0.67 mol) in 1,2-dichloroethane (600 ml) was added chloroacetyl chloride (55.7 ml. 78.9 g, 0.7 mol) dropwise at 0-5° C. under nitrogen for 20 minutes and it was then left to warm up to 20-25° C. To this mixture was added N-trifluoroacetyl-(R)-1-aminoindan (34.4 g, 0.15 mol) for 3 hours at 20-25° C. The resulting mixture was then stirred or an additional 30 minutes and poured into a mixture of ice-cold water (1.5 l) and 1,2-dichloroethane (11). The mixture was stirred for 5 minutes and the layers were separated. The aqueous layer was extracted with 1,2-dichloroethane (2×750 ml). The combined organic layers were washed with water (2×900 ml) and 5% aqueous NaHCO3 solution (3×900 ml). The organic layer was dried (Na2SO4) and the solvent was removed under reduced pressure to give a solid, which was recrystallized from ethanol to give 15 g (48%) of a white solid mp: 166-167° C. it was then left The mixture was stirred for 5 minutes the layers were separated The aqueous layer was extracted with 1,2-dichloroethane (2×750 ml) The combined organic layers were washed with water (2×900 ml) and 5% aqueous NaHCO3 solution (3×900 ml) The organic layer was dried (Na2SO4) the solvent was removed under reduced pressure to give a solid, which was recrystallized from ethanol

反応条件: temp:22.51; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a suspension of AlCl3 (89.2 g, 0.67 mol) in 1,2-dichloroethane (600 ml) was added chloroacetyl chloride (55.7 ml. 78.9 g, 0.7 mol) dropwise at 0-5° C. under nitrogen for 20 minutes and it was then left to warm up to 20-25° C. To this mixture was added N-trifluoroacetyl-(R)-1-aminoindan (34.4 g, 0.15 mol) for 3 hours at 20-25° C. The resulting mixture was then stirred or an additional 30 minutes and poured into a mixture of ice-cold water (1.5 l) and 1,2-dichloroethane (11). The mixture was stirred for 5 minutes and the layers were separated. The aqueous layer was extracted with 1,2-dichloroethane (2×750 ml). The combined organic layers were washed with water (2×900 ml) and 5% aqueous NaHCO3 solution (3×900 ml). The organic layer was dried (Na2SO4) and the solvent was removed under reduced pressure to give a solid, which was recrystallized from ethanol to give 15 g (48%) of a white solid mp: 166-167° C. it was then left The mixture was stirred for 5 minutes the layers were separated The aqueous layer was extracted with 1,2-dichloroethane (2×750 ml) The combined organic layers were washed with water (2×900 ml) and 5% aqueous NaHCO3 solution (3×900 ml) The organic layer was dried (Na2SO4) the solvent was removed under reduced pressure to give a solid, which was recrystallized from ethanol

反応条件: temp:22.51; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a suspension of AlCl3 (89.2 g, 0.67 mol) in 1,2-dichloroethane (600 ml) was added chloroacetyl chloride (55.7 ml. 78.9 g, 0.7 mol) dropwise at 0-5° C. under nitrogen for 20 minutes and it was then left to warm up to 20-25° C. To this mixture was added N-trifluoroacetyl-(R)-1-aminoindan (34.4 g, 0.15 mol) for 3 hours at 20-25° C. The resulting mixture was then stirred or an additional 30 minutes and poured into a mixture of ice-cold water (1.5 l) and 1,2-dichloroethane (11). The mixture was stirred for 5 minutes and the layers were separated. The aqueous layer was extracted with 1,2-dichloroethane (2×750 ml). The combined organic layers were washed with water (2×900 ml) and 5% aqueous NaHCO3 solution (3×900 ml). The organic layer was dried (Na2SO4) and the solvent was removed under reduced pressure to give a solid, which was recrystallized from ethanol to give 15 g (48%) of a white solid mp: 166-167° C. it was then left The mixture was stirred for 5 minutes the layers were separated The aqueous layer was extracted with 1,2-dichloroethane (2×750 ml) The combined organic layers were washed with water (2×900 ml) and 5% aqueous NaHCO3 solution (3×900 ml) The organic layer was dried (Na2SO4) the solvent was removed under reduced pressure to give a solid, which was recrystallized from ethanol

反応条件: temp:22.51; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a suspension of AlCl3 (89.2 g, 0.67 mol) in 1,2-dichloroethane (600 ml) was added chloroacetyl chloride (55.7 ml, 78.9 g, 0.7 mol) dropwise at 0-5° C. under nitrogen for 20 minutes and it was then left to warm up to 20-25° C. To this mixture was added N-trifluoroacetyl-(R)-1-aminoindan (34.4 g, 0.15 mol) for 3 hours at 20-25° C. The resulting mixture was then stirred for an additional 30 minutes and poured into a mixture of ice-cold water (1.5 l) and 1,2-dichloroethane (1l). The mixture was stirred for 5 minutes and the layers were separated. The aqueous layer was extracted with 1,2-dichloroethane (2×750 ml). The combined organic layers were washed with water (2×900 ml) and 5% aqueous NaHCO3 solution (3×900 ml). The organic layer was dried (Na2SO4) and the solvent was removed under reduced pressure to give a solid, which was recrystallized from ethanol to give 15 g (48%) of a white solid mp: 166-167° C. it was then left The mixture was stirred for 5 minutes the layers were separated The aqueous layer was extracted with 1,2-dichloroethane (2×750 ml) The combined organic layers were washed with water (2×900 ml) and 5% aqueous NaHCO3 solution (3×900 ml) The organic layer was dried (Na2SO4) the solvent was removed under reduced pressure to give a solid, which was recrystallized from ethanol

反応条件: temp:22.51; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a suspension of AlCl3 (89.2 g, 0.67 mol) in 1,2-dichloroethane (600 ml) was added chloroacetyl chloride (55.7 ml, 78.9 g, 0.7 mol) dropwise at 0-5° C. under nitrogen for 20 minutes and it was then left to warm up to 20-25° C. To this mixture was added N-trifluoroacetyl-(R)-1-aminoindan (34.4 g, 0.15 mol) for 3 hours at 20-25° C. The resulting mixture was then stirred for an additional 30 minutes and poured into a mixture of ice-cold water (1.5 l) and 1,2-dichloroethane (1l). The mixture was stirred for 5 minutes and the layers were separated. The aqueous layer was extracted with 1,2-dichloroethane (2×750 ml). The combined organic layers were washed with water (2×900 ml) and 5% aqueous NaHCO3 solution (3×900 ml). The organic layer was dried (Na2SO4) and the solvent was removed under reduced pressure to give a solid, which was recrystallized from ethanol to give 15 g (48%) of a white solid mp: 166-167° C. it was then left The mixture was stirred for 5 minutes the layers were separated The aqueous layer was extracted with 1,2-dichloroethane (2×750 ml) The combined organic layers were washed with water (2×900 ml) and 5% aqueous NaHCO3 solution (3×900 ml) The organic layer was dried (Na2SO4) the solvent was removed under reduced pressure to give a solid, which was recrystallized from ethanol

反応条件: temp:22.51; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a suspension of AlCl3 (89.2 g, 0.67 mol) in 1,2-dichloroethane (600 ml) was added chloroacetyl chloride (55.7 ml. 78.9 g, 0.7 mol) dropwise at 0-5° C. under nitrogen for 20 minutes and it was then left to warm up to 20-25° C. To this mixture was added N-trifluoroacetyl-(R)-1-aminoindan (34.4 g, 0.15 mol) for 3 hours at 20-25° C. The resulting mixture was then stirred or an additional 30 minutes and poured into a mixture of ice-cold water (1.5 l) and 1,2-dichloroethane (11). The mixture was stirred for 5 minutes and the layers were separated. The aqueous layer was extracted with 1,2-dichloroethane (2×750 ml). The combined organic layers were washed with water (2×900 ml) and 5% aqueous NaHCO3 solution (3×900 ml). The organic layer was dried (Na2SO4) and the solvent was removed under reduced pressure to give a solid, which was recrystallized from ethanol to give 15 g (48%) of a white solid mp: 166-167° C. it was then left The mixture was stirred for 5 minutes the layers were separated The aqueous layer was extracted with 1,2-dichloroethane (2×750 ml) The combined organic layers were washed with water (2×900 ml) and 5% aqueous NaHCO3 solution (3×900 ml) The organic layer was dried (Na2SO4) the solvent was removed under reduced pressure to give a solid, which was recrystallized from ethanol