ethyl 4-cyano-1H-pyrrole-3-carboxylate

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a solution of 4-cyano-1H-pyrrole-3-carboxylic acid ethyl ester (1.1 g) in methanol (65 mL) was added 1 mol/L aqueous sodium hydroxide solution (65 mL), and this mixture was stirred at 50° C. for 5 hours. To this reaction mixture was added 1 mol/L hydrochloric acid, this mixture was extracted with ethyl acetate. This organic layer was washed with brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure. This obtained residue was washed with diethyl ether to give the title compound (0.72 g). this mixture was extracted with ethyl acetate This organic layer was washed with brine dried over anhydrous magnesium sulfate The solvent was removed under reduced pressure This obtained residue was washed with diethyl ether

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a solution of 4-cyano-1H-pyrrole-3-carboxylic acid ethyl ester (1.1 g) in methanol (65 mL) was added 1 mol/L aqueous sodium hydroxide solution (65 mL), and this mixture was stirred at 50° C. for 5 hours. To this reaction mixture was added 1 mol/L hydrochloric acid, this mixture was extracted with ethyl acetate. This organic layer was washed with brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure. This obtained residue was washed with diethyl ether to give the title compound (0.72 g). this mixture was extracted with ethyl acetate This organic layer was washed with brine dried over anhydrous magnesium sulfate The solvent was removed under reduced pressure This obtained residue was washed with diethyl ether

反応条件: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a solution of 4-cyano-1H-pyrrole-3-carboxylic acid ethyl ester (1.1 g) in methanol (65 mL) was added 1 mol/L aqueous sodium hydroxide solution (65 mL), and this mixture was stirred at 50° C. for 5 hours. To this reaction mixture was added 1 mol/L hydrochloric acid, this mixture was extracted with ethyl acetate. This organic layer was washed with brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure. This obtained residue was washed with diethyl ether to give the title compound (0.72 g). this mixture was extracted with ethyl acetate This organic layer was washed with brine dried over anhydrous magnesium sulfate The solvent was removed under reduced pressure This obtained residue was washed with diethyl ether