tert-butyl (3R)-3-aminobutanoate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The compound was prepared according to the general preparation processes, steps A, B, D, E and J. In step D, tert-butyl (S)-2-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetate was alkylated with 4-benzyloxybenzyl bromide. In step J, the amino compound employed was tert-butyl (R)-3-amino-3-methylpropionate. The compound was prepared according to the general preparation processes, steps A, B, D, E and J

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The compound was prepared according to the general preparation processes, steps A, B, D, E and J. In step D, tert-butyl (S)-2-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetate was alkylated with 4-chloromethylstilbene. In step J, tert-butyl (R)-3-amino-3-methylpropionate was employed as an amino compound. The compound was prepared according to the general preparation processes, steps A, B, D, E and J

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The compound was prepared according to the general preparation processes, steps A, B, D, E and J. In step D, tert-butyl (S)-2-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetate was alkylated with 4-chloromethylstilbene. In step J, tert-butyl (R)-3-amino-3-methylpropionate was employed as an amino compound. The compound was prepared according to the general preparation processes, steps A, B, D, E and J

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[2-(2-oxo-1-piperidinyl)ethyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 1,1-dimethylethyl (3R)-3-aminobutanoate using methods similar to Example 563 to provide an orange solid: ES+ MS: 581 (M+H+). to provide an orange solid

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: which had been prepared from (S)-2-(4,4-bis(trifluoromethyl)-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetic acid and 4-(3-(2-methylphenyl)ureido)-3-methoxybenzyl chloride as described in Example 18f, and 128 mg (0.809 mmol) of tert-butyl (R)-3-aminobutanoate. After coupling, chromatographic purification over silica gel (eluent: heptane/ethyl acetate=3/2) and cleavage of the tert-butyl ester, 299 mg (53%) of the title compound were obtained. chromatographic purification over silica gel (eluent: heptane/ethyl acetate=3/2) and cleavage of the tert-butyl ester

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The compound was prepared according to the general preparation processes, steps A, B, D, E and J. In step D, tert-butyl (S)-2-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetate was alkylated with 4-benzyloxybenzyl bromide. In step J, the amino compound employed was tert-butyl (R)-3-amino-3-methylpropionate. The compound was prepared according to the general preparation processes, steps A, B, D, E and J

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The compound was prepared according to the general preparation processes, steps A, B, D, E and J. In step D, tert-butyl (S)-2-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetate was alkylated with 4-chloromethylstilbene. In step J, tert-butyl (R)-3-amino-3-methylpropionate was employed as an amino compound. The compound was prepared according to the general preparation processes, steps A, B, D, E and J