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CNS(=O)(=O)CCCCCl製品情報
4-chloro-N-methylbutane-1-sulfonamide (CAS 16867-22-4) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
想定用途
専門的研究・工業用途限定
データベース ID 10375164
安全上の注意
For professional research and industrial use only. Review the supplier safety data sheet before handling.
合成データ
12 反応 · 12 文献
反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-28a9316fbef64d1e9f2e8e1512bc1dd9反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-a27f783c284a41ffbfd2976e3e69a274反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 4-Chloro-N-methylbutane-1-sulfonamide (54 mmol), KCN (108 mmol) and 18-crown ether-6 (11 mmol) were dissolved in CH3CN (100 ml). The mixture was stirred at reflux temperature overnight. The mixture was cooled and filtered. The residue was purified by flash column chromatography over silica gel (eluent: CH2Cl2, then ethyl acetate). Yield: 3.2 g (70% purity). at reflux temperature overnight The mixture was cooled filtered The residue was purified by flash column chromatography over silica gel (eluent
ソース ID: ord-65ee3938be8f4713a3559e2edf75039d反応条件: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A solution of 4-chloro-N-methylbutane-1-sulfonamide (Example 5; 86.7 mmol), and sodium iodide (95.4 mmol) in DMF (175 ml) was stirred for 10 min at room temperature. Sodium cyanide (191 mmol) was added and the mixture was stirred overnight at 60° C. The mixture was filtered off and the filtrate was extracted with AcOEt/water. The crude product was concentrated and was used without further purification in the next step (Examples 10 and 20). The mixture was filtered off the filtrate was extracted with AcOEt/water The crude product was concentrated was used without further purification in the next step (Examples 10 and 20)
ソース ID: ord-99d6bf23ddb54976be121c9d2c8291d3反応条件: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A solution of 4-chloro-N-methylbutane-1-sulfonamide (Example 5; 180 mmol), and sodium iodide (198 mmol) in DMF (180 ml) was stirred for 10 min at room temperature. Sodium azide (397 mmol) was added and the reaction mixture was stirred overnight at 60° C. The mixture was filtered off The organic phase was extracted with AcOEt/water. The crude mixture was concentrated and was used without further purification in the next step. The mixture was filtered off The organic phase was extracted with AcOEt/water The crude mixture was concentrated was used without further purification in the next step
ソース ID: ord-eef268d98bd746fba84d38bbd2f42d63反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a solution of 4-chlorobutane-1-sulfonyl chloride (117 mmol) and triethyl amine (117 mmol) in dichloro methane (250 ml) at 0° C. was added a 2M solution of methyl amine in THF (117 mmol) dropwise. The mixture was allowed to warm to room temperature with stirring overnight. The organic solution was washed with H2O and extracted with CH2Cl2, dried over MgSO4 and filtered. The solution was concentrated. The product was used without further purification. The organic solution was washed with H2O extracted with CH2Cl2 dried over MgSO4 filtered The solution was concentrated The product was used without further purification
ソース ID: ord-973a1751c9bc4dd493d5322be9346561反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-28a9316fbef64d1e9f2e8e1512bc1dd9反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-a27f783c284a41ffbfd2976e3e69a274反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 4-Chloro-N-methylbutane-1-sulfonamide (54 mmol), KCN (108 mmol) and 18-crown ether-6 (11 mmol) were dissolved in CH3CN (100 ml). The mixture was stirred at reflux temperature overnight. The mixture was cooled and filtered. The residue was purified by flash column chromatography over silica gel (eluent: CH2Cl2, then ethyl acetate). Yield: 3.2 g (70% purity). at reflux temperature overnight The mixture was cooled filtered The residue was purified by flash column chromatography over silica gel (eluent
ソース ID: ord-65ee3938be8f4713a3559e2edf75039d反応条件: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A solution of 4-chloro-N-methylbutane-1-sulfonamide (Example 5; 86.7 mmol), and sodium iodide (95.4 mmol) in DMF (175 ml) was stirred for 10 min at room temperature. Sodium cyanide (191 mmol) was added and the mixture was stirred overnight at 60° C. The mixture was filtered off and the filtrate was extracted with AcOEt/water. The crude product was concentrated and was used without further purification in the next step (Examples 10 and 20). The mixture was filtered off the filtrate was extracted with AcOEt/water The crude product was concentrated was used without further purification in the next step (Examples 10 and 20)
ソース ID: ord-99d6bf23ddb54976be121c9d2c8291d3反応条件: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A solution of 4-chloro-N-methylbutane-1-sulfonamide (Example 5; 180 mmol), and sodium iodide (198 mmol) in DMF (180 ml) was stirred for 10 min at room temperature. Sodium azide (397 mmol) was added and the reaction mixture was stirred overnight at 60° C. The mixture was filtered off The organic phase was extracted with AcOEt/water. The crude mixture was concentrated and was used without further purification in the next step. The mixture was filtered off The organic phase was extracted with AcOEt/water The crude mixture was concentrated was used without further purification in the next step
ソース ID: ord-eef268d98bd746fba84d38bbd2f42d63反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a solution of 4-chlorobutane-1-sulfonyl chloride (117 mmol) and triethyl amine (117 mmol) in dichloro methane (250 ml) at 0° C. was added a 2M solution of methyl amine in THF (117 mmol) dropwise. The mixture was allowed to warm to room temperature with stirring overnight. The organic solution was washed with H2O and extracted with CH2Cl2, dried over MgSO4 and filtered. The solution was concentrated. The product was used without further purification. The organic solution was washed with H2O extracted with CH2Cl2 dried over MgSO4 filtered The solution was concentrated The product was used without further purification
ソース ID: ord-973a1751c9bc4dd493d5322be9346561PubChem References
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