177034-25-2

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: According to the procedure for Intermediate 370.2, 1-methyl-3-phenyl-1H-1,2,4-triazole (70 mg, 0.44 mmol) and Intermediate 391.1 (80 mg, 0.48 mmol) afforded 108 mg of Intermediate 391.2 as a white solid. LCMS 332.28 (M+H).

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To 98A (506 mg, 2.94 mmol) in ethyl acetate (10 mL) was added a solution of KCN (574 mg, 8.82 mmol) and NaHSO3 (917 mg, 8.82 mmol) dissolved in H2O (10 mL). The reaction was stirred at rt for 48 h. It was extracted with ethyl acetate (2×50 mL). The combined organic extracts were dried and concentrated to give 98B as an oil. It was used for next step without purification. It was extracted with ethyl acetate (2×50 mL) The combined organic extracts were dried concentrated