2,6-dimethylheptane-3,5-dione

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture comprising 17.2 g (110 mmol) of 2,6-dimethyl-3,5-heptanedione, 22.8 g (153 mmol) of ethyl orthoformate and 31.5 g (309 mmol) of acetic anhydride, was reacted for 2 hours at 110° C. The solvent was distilled off under reduced pressure to obtain 11.5 g (yield: 49%) of 4-ethoxymethylene-2,6-dimethyl-3,5-heptanedione. The solvent was distilled off under reduced pressure

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture comprising 17.2 g (110 mmol) of 2,6-dimethyl-3,5-heptanedione, 22.8 g (153 mmol) of ethyl orthoformate and 31.5 g (309 mmol) of acetic anhydride, was reacted for 2 hours at 110° C. The solvent was distilled off under reduced pressure to obtain 11.5 g (yield: 49%) of 4-ethoxymethylene-2,6-dimethyl-3,5-heptanedione. The solvent was distilled off under reduced pressure

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture comprising 17.2 g (110 mmol) of 2,6-dimethyl-3,5-heptanedione, 22.8 g (153 mmol) of ethyl orthoformate and 31.5 g (309 mmol) of acetic anhydride, was reacted for 2 hours at 110° C. The solvent was distilled off under reduced pressure to obtain 11.5 g (yield: 49%) of 4-ethoxymethylene-2,6-dimethyl-3,5-heptanedione. The solvent was distilled off under reduced pressure

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Synthesis procedure was similar to that described in synthetic example 19(1), except that 3,5-heptandione was replaced by 2,6-dimethyl-3,5-heptandione, and finally the product was purified by distilling under reduced pressure. 2,6-dimethyl-3,5-heptandiol as a colorless liquid was obtained with a yield of 90%. Synthesis procedure finally the product was purified by distilling under reduced pressure

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Synthesis procedure was similar to that described in synthetic example 19(1), except that 3,5-heptandione was replaced by 2,6-dimethyl-3,5-heptandione, and finally the product was purified by distilling under reduced pressure. 2,6-dimethyl-3,5-heptandiol as a colorless liquid was obtained with a yield of 90%. Synthesis procedure finally the product was purified by distilling under reduced pressure

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The title compound was prepared from (2-Amino-5-bromo-phenyl)-phenyl-methanone [example A16] and 2,6-dimethyl-3,5-heptanedione according to the method of example 1, except that the reaction time was of 96 h and the residue was purified by chromatography on aminated silica gel with heptane/ethyl acetate (85:15). Yield: 46%. MS: m/z=395/397 (M). the residue was purified by chromatography on aminated silica gel with heptane/ethyl acetate (85:15)

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The procedure was the same as the one for the preparation of 3,5-diethylpyrrol-2-carboxaldehyde except starting with 2,6-dimethyl-3,5-heptanedione.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The title compound was prepared according to the experimentals described for Example 22 above from 3-[3-(4-fluorophenoxy)propyl]-1H-1,2,4-triazol-5-amine and 2,6-dimethyl-3,5-heptanedione in 61% yield. The reagent 3-[3-(4-fluorophenoxy)propyl]-1H-1,2,4-triazol-5-amine was prepared by a similar procedure for the synthesis of 3-[3-(4-chlorophenoxy)propyl]-1H-1,2,4-triazol-5-amine in Example 22 above, beginning from 4-fluorophenol instead of 4-chlorophenol. EM (calc.): 356.2; MS (ESI) m/e: 357.4 (M+H)+.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The procedure was the same as the one for the preparation of 3,5-diethylpyrrol-2-carboxaldehyde except starting with 2,6-dimethyl-3,5-heptanedione.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture comprising 17.2 g (110 mmol) of 2,6-dimethyl-3,5-heptanedione, 22.8 g (153 mmol) of ethyl orthoformate and 31.5 g (309 mmol) of acetic anhydride, was reacted for 2 hours at 110° C. The solvent was distilled off under reduced pressure to obtain 11.5 g (yield: 49%) of 4-ethoxymethylene-2,6-dimethyl-3,5-heptanedione. The solvent was distilled off under reduced pressure

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Synthesis procedure was similar to that described in synthetic example 19(1), except that 3,5-heptandione was replaced by 2,6-dimethyl-3,5-heptandione, and finally the product was purified by distilling under reduced pressure. 2,6-dimethyl-3,5-heptandiol as a colorless liquid was obtained with a yield of 90%. Synthesis procedure finally the product was purified by distilling under reduced pressure