diethyl 2-(3-chloropropyl)propanedioate

反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 200 mg (0.53 mmol) of 1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperazine were dissolved in 5 ml of NMP, 235 μl (1.06 mmol) of 2-(3-chloropropyl)malonic acid diethyl ester and 220 μl (1.59 mmol) of triethylamine were added, and the mixture was stirred at 100° C. overnight. The reaction mixture was evaporated to dryness and purified by means of preparative HPLC. The product is in the form of the TFA salt. The reaction mixture was evaporated to dryness purified by means of preparative HPLC

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The preparation was carried out analogously as described above starting from 200 mg (0.53 mmol) of 1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperazine and 234 μl (0.1.06 mmol) of 2-(3-chloropropyl)malonic acid diethyl ester and subsequent reduction using lithium aluminium hydride prepared. The product is in the form of the hydrochloride. prepared