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C1CNC(CN1)C#N製品情報
piperazine-2-carbonitrile (CAS 187589-36-2) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
想定用途
専門的研究・工業用途限定
データベース ID 9813119
安全上の注意
For professional research and industrial use only. Review the supplier safety data sheet before handling.
合成データ
10 反応 · 10 文献
反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-6574374e689f44cd9d878e005883f1c6反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-6d0e1630fea8479ab8e0ad15f0a5bfc5反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a mixture of 2-(4,5-dichloro-2-methoxyphenylamino)acetic acid (260 mg, 1.04 mmol), EDCI (273 mg, 1.43 mmol), HOBt (194 mg, 1.43 mmol) and Et3N (288 mg 2.85 mmol) in DCM (10 mL) at 0° C., piperazine-2-carbonitrile was added. The resulting mixture was stirred at RT for 8 h. The mixture was partitioned between dichloromethane and water. The organic layer was washed with brine, dried over MgSO4, filtered and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel (dichloromethane/methanol=50:1) to afford the desired product (108 mg, 30% yield). The mixture was partitioned between dichloromethane and water The organic layer was washed with brine dried over MgSO4 filtered concentrated in vacuo The residue was purified by flash column chromatography on silica gel (dichloromethane/methanol=50:1)
ソース ID: ord-96b65f4b40b3479cbd3ab85bbecef5c2反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a mixture of 2-(4,5-dichloro-2-methoxyphenylamino)acetic acid (260 mg, 1.04 mmol), EDCI (273 mg, 1.43 mmol), HOBt (194 mg, 1.43 mmol) and Et3N (288 mg 2.85 mmol) in DCM (10 mL) at 0° C., piperazine-2-carbonitrile was added. The resulting mixture was stirred at RT for 8 h. The mixture was partitioned between dichloromethane and water. The organic layer was washed with brine, dried over MgSO4, filtered and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel (dichloromethane/methanol=50:1) to afford the desired product (108 mg, 30% yield). The mixture was partitioned between dichloromethane and water The organic layer was washed with brine dried over MgSO4 filtered concentrated in vacuo The residue was purified by flash column chromatography on silica gel (dichloromethane/methanol=50:1)
ソース ID: ord-96b65f4b40b3479cbd3ab85bbecef5c2反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a mixture of 4′,6-dichloro-4-methoxy-[1,1′-biphenyl]-3-carboxylic acid (309 mg, 1.04 mmol), EDCI (272 mg, 1.43 mmol), HOBt (195 mg, 1.43 mmol), Et3N (288 mg, 2.85 mmol) in dichloromethane (10 mL) at 0° C., piperazine-2-carbonitrile was added at 0° C. and the resulting mixture was stirred at RT for 8 h. The mixture was partitioned between dichloromethane and water. The organic layer was washed brine, dried over MgSO4, filtered and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel (dichloromethane/methanol=50:1) to afford the desired product (225 mg, 61% yield). ESI-MS m/z: 444.3[M+H]+. The mixture was partitioned between dichloromethane and water The organic layer was washed brine dried over MgSO4 filtered concentrated in vacuo The residue was purified by flash column chromatography on silica gel (dichloromethane/methanol=50:1)
ソース ID: ord-2bb437ae6ea447769706f6ae09de5a34反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-6574374e689f44cd9d878e005883f1c6反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-6d0e1630fea8479ab8e0ad15f0a5bfc5反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a mixture of 2-(4,5-dichloro-2-methoxyphenylamino)acetic acid (260 mg, 1.04 mmol), EDCI (273 mg, 1.43 mmol), HOBt (194 mg, 1.43 mmol) and Et3N (288 mg 2.85 mmol) in DCM (10 mL) at 0° C., piperazine-2-carbonitrile was added. The resulting mixture was stirred at RT for 8 h. The mixture was partitioned between dichloromethane and water. The organic layer was washed with brine, dried over MgSO4, filtered and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel (dichloromethane/methanol=50:1) to afford the desired product (108 mg, 30% yield). The mixture was partitioned between dichloromethane and water The organic layer was washed with brine dried over MgSO4 filtered concentrated in vacuo The residue was purified by flash column chromatography on silica gel (dichloromethane/methanol=50:1)
ソース ID: ord-96b65f4b40b3479cbd3ab85bbecef5c2反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a mixture of 4′,6-dichloro-4-methoxy-[1,1′-biphenyl]-3-carboxylic acid (309 mg, 1.04 mmol), EDCI (272 mg, 1.43 mmol), HOBt (195 mg, 1.43 mmol), Et3N (288 mg, 2.85 mmol) in dichloromethane (10 mL) at 0° C., piperazine-2-carbonitrile was added at 0° C. and the resulting mixture was stirred at RT for 8 h. The mixture was partitioned between dichloromethane and water. The organic layer was washed brine, dried over MgSO4, filtered and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel (dichloromethane/methanol=50:1) to afford the desired product (225 mg, 61% yield). ESI-MS m/z: 444.3[M+H]+. The mixture was partitioned between dichloromethane and water The organic layer was washed brine dried over MgSO4 filtered concentrated in vacuo The residue was purified by flash column chromatography on silica gel (dichloromethane/methanol=50:1)
ソース ID: ord-2bb437ae6ea447769706f6ae09de5a34反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-6574374e689f44cd9d878e005883f1c6PubChem References
化合物の公開データベース記録に掲載された情報源です。