(2S)-2-amino-2-(4-chlorophenyl)ethanol

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of L-4-chloro-phenylglycine (1.74 g, 9.37 mmol) and LAH (712 mg, 18.75 mmol) in THF (40 mL) is refluxed for 1.5 h. After completion, the reaction mixture is quenched by Na2SO4.10H2O and the product is isolated by filtration with Celite, washed with THF and dried under reduced pressure to give the title compound as oil; HPLC: AtRet=1.46 min; 1HNMR (DMSO-d6) 7.35 (d, 2H), 7.30 (d, 2H), 4.80 (bs, 1H), 3.85-3.80 (m, 1H), 3.45-3.20 (m, 2H), 1.85 (bs, 2H). is refluxed for 1.5 h After completion, the reaction mixture is quenched by Na2SO4.10H2O the product is isolated by filtration with Celite washed with THF dried under reduced pressure

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of L-4-chloro-phenylglycine (1.74 g, 9.37 mmol) and LAH (712 mg, 18.75 mmol) in THF (40 mL) is refluxed for 1.5 h. After completion, the reaction mixture is quenched by Na2SO4.10H2O and the product is isolated by filtration with Celite, washed with THF and dried under reduced pressure to give the title compound as oil; HPLC: AtRet=1.46 min; 1HNMR (DMSO-d6) 7.35 (d, 2H), 7.30 (d, 2H), 4.80 (bs, 1H), 3.85-3.80 (m, 1H), 3.45-3.20 (m, 2H), 1.85 (bs, 2H). is refluxed for 1.5 h After completion, the reaction mixture is quenched by Na2SO4.10H2O the product is isolated by filtration with Celite washed with THF dried under reduced pressure

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of L-4-chloro-phenylglycine (1.74 g, 9.37 mmol) and LAH (712 mg, 18.75 mmol) in THF (40 mL) is refluxed for 1.5 h. After completion, the reaction mixture is quenched by Na2SO4.10H2O and the product is isolated by filtration with Celite, washed with THF and dried under reduced pressure to give the title compound as oil; HPLC: AtRet=1.46 min; 1HNMR (DMSO-d6) 7.35 (d, 2H), 7.30 (d, 2H), 4.80 (bs, 1H), 3.85-3.80 (m, 1H), 3.45-3.20 (m, 2H), 1.85 (bs, 2H). is refluxed for 1.5 h After completion, the reaction mixture is quenched by Na2SO4.10H2O the product is isolated by filtration with Celite washed with THF dried under reduced pressure