2-(2-methylphenyl)-3H-pyrazol-4-one

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of methyl (4-chloro-2,6-dimethyl-5-pyrimidinyl)-acetate (4.6 g, 21 mmol), 1-(2-methylphenyl)-1H-pyrazol-4-on (4.1 g, 23 mmol) and potassium carbonate (6.4 g, 46 mmol) in dimethylformamide (50 ml) is heated at +120° C. for 2 hours. Addition of water, extraction with ether and drying gives the intermediate methyl 2-[2,4-dimethyl-6-(1-(2-methylphenyl)-1H-pyrazol4-yloxy)-pyrimidin-5-yl]-acetate as an oil. is heated at +120° C. for 2 hours drying

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of methyl (4-chloro-2,6-dimethyl-5-pyrimidinyl)-acetate (4.6 g, 21 mmol), 1-(2-methylphenyl)-1H-pyrazol-4-on (4.1 g, 23 mmol) and potassium carbonate (6.4 g, 46 mmol) in dimethylformamide (50 ml) is heated at +120° C. for 2 hours. Addition of water, extraction with ether and drying gives the intermediate methyl 2-[2,4-dimethyl-6-(1-(2-methylphenyl)-1H-pyrazol4-yloxy)-pyrimidin-5-yl]-acetate as an oil. is heated at +120° C. for 2 hours drying