sodium;pentan-1-olate

反応条件: temp:130.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 6-Amino-9-benzyl-2-chloropurine (150 mg, 0.58 mmol) and sodium pentylate (318 mg, 2.89 mmol) were dissolved in 1-pentanol (50 ml) and then the solution was stirred under heating at 130° C. for 5 hours. The reaction mixture was evaporated in vacuo to dryness. To the residue was added water and the mixture was extracted with chloroform. The organic layer was dried on sodium sulfate and evaporated in vacuo to dryness. The residue was purified with silica gel chromatography (2% methanol/chloroform) to give the subject compound (103 mg, yield 57%). The reaction mixture was evaporated in vacuo to dryness To the residue was added water the mixture was extracted with chloroform The organic layer was dried on sodium sulfate evaporated in vacuo to dryness The residue was purified with silica gel chromatography (2% methanol/chloroform)