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C1=CC=C(C=C1)S(=O)(=O)CCCCl製品情報
3-chloropropylsulfonylbenzene (CAS 19432-96-3) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
想定用途
専門的研究・工業用途限定
データベース ID 11769949
安全上の注意
For professional research and industrial use only. Review the supplier safety data sheet before handling.
合成データ
12 反応 · 12 文献
反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-e530eff72b2c447aa9172de0e5a5128f反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-e1a37fed4f42486a85fb79b2754e3979反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-4910c82bb2c34a60813c2628d070c81e反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride and 3-phenylsulfonylpropyl chloride were reacted and treated in the same manner as in Example 199 to give 4-amino-5-chloro-2-methoxy-N-((1-(3-(phenylsulfonyl)propyl)piperidin-4-yl)methyl)-benzamide. treated in the same manner as in Example 199
ソース ID: ord-97cd001a45d44363ac71c55ff722d911反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-e530eff72b2c447aa9172de0e5a5128f反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-e530eff72b2c447aa9172de0e5a5128f反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A solution of 66.55 g (0.3052 mole) of 3-chloropropylphenyl sulfone (prepared by reacting m-chloroperoxybenzoic acid and 3-chloropropyl phenylsulfide in methylene chloride) in 200 ml of isopropylamine was heated at 100° C. overnight in a bomb. The isopropylamine was removed by rotary evaporation and the residue partitioned between chloroform and water. The chloroform layer was extracted with 1N sulfuric acid. The acidic layer was made alkaline and extracted with chloroform. The combined chloroform extract was evaporated to give an oil, the free base of the title compound. The oil was converted to the hydrochloride salt by reacting with ethereal hydrogen chloride. Recrystallization of the precipitated salt from methanol-diethyl ether gave 48.04 g (65.3%) of white crystalline powder, m.p. 185°-186° C. The isopropylamine was removed by rotary evaporation the residue partitioned between chloroform and water The chloroform layer was extracted with 1N sulfuric acid extracted with chloroform The combined chloroform extract was evaporated to give an oil
ソース ID: ord-42a70ce1422f439ebb9c5d10762eab4f反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A solution of 66.55 g (0.3052 mole) of 3-chloropropylphenyl sulfone (prepared by reacting m-chloroperoxybenzoic acid and 3-chloropropyl phenylsulfide in methylene chloride) in 200 ml of isopropylamine was heated at 100° C. overnight in a bomb. The isopropylamine was removed by rotary evaporation and the residue partitioned between chloroform and water. The chloroform layer was extracted with 1N sulfuric acid. The acidic layer was made alkaline and extracted with chloroform. The combined chloroform extract was evaporated to give an oil, the free base of the title compound. The oil was converted to the hydrochloride salt by reacting with ethereal hydrogen chloride. Recrystallization of the precipitated salt from methanol-diethyl ether gave 48.04 g (65.3%) of white crystalline powder, m.p. 185°-186° C. The isopropylamine was removed by rotary evaporation the residue partitioned between chloroform and water The chloroform layer was extracted with 1N sulfuric acid extracted with chloroform The combined chloroform extract was evaporated to give an oil
ソース ID: ord-42a70ce1422f439ebb9c5d10762eab4f反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride and 3-phenylsulfonylpropyl chloride were reacted and treated in the same manner as in Example 199 to give 4-amino-5-chloro-2-methoxy-N-((1-(3-(phenylsulfonyl)propyl)piperidin-4-yl)methyl)-benzamide. treated in the same manner as in Example 199
ソース ID: ord-97cd001a45d44363ac71c55ff722d911反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A solution of 66.55 g (0.3052 mole) of 3-chloropropylphenyl sulfone (prepared by reacting m-chloroperoxybenzoic acid and 3-chloropropyl phenylsulfide in methylene chloride) in 200 ml of isopropylamine was heated at 100° C. overnight in a bomb. The isopropylamine was removed by rotary evaporation and the residue partitioned between chloroform and water. The chloroform layer was extracted with 1N sulfuric acid. The acidic layer was made alkaline and extracted with chloroform. The combined chloroform extract was evaporated to give an oil, the free base of the title compound. The oil was converted to the hydrochloride salt by reacting with ethereal hydrogen chloride. Recrystallization of the precipitated salt from methanol-diethyl ether gave 48.04 g (65.3%) of white crystalline powder, m.p. 185°-186° C. The isopropylamine was removed by rotary evaporation the residue partitioned between chloroform and water The chloroform layer was extracted with 1N sulfuric acid extracted with chloroform The combined chloroform extract was evaporated to give an oil
ソース ID: ord-3899e2d65d6d4b47ba44772811d58aca反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-e1a37fed4f42486a85fb79b2754e3979反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-4910c82bb2c34a60813c2628d070c81ePubChem References
化合物の公開データベース記録に掲載された情報源です。
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