6-methyl-5-phenylmethoxy-1H-indole

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:220.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a solution of 5-benzyloxy-6-methyl-1H-indole-2-carboxylic acid (0.6 g) in quinoline (6 mL) was added copper powder (0.15 g), and this mixture was stirred at 220° C. for 20 minutes. This reaction mixture was poured into 1 mol/L hydrochloric acid, the resulting mixture was extracted with ethyl acetate. This organic layer was washed with brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate) to give the title compound (0.21 g). the resulting mixture was extracted with ethyl acetate This organic layer was washed with brine dried over anhydrous magnesium sulfate The solvent was removed under reduced pressure The residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate)

反応条件: temp:220.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a solution of 5-benzyloxy-6-methyl-1H-indole-2-carboxylic acid (0.6 g) in quinoline (6 mL) was added copper powder (0.15 g), and this mixture was stirred at 220° C. for 20 minutes. This reaction mixture was poured into 1 mol/L hydrochloric acid, the resulting mixture was extracted with ethyl acetate. This organic layer was washed with brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate) to give the title compound (0.21 g). the resulting mixture was extracted with ethyl acetate This organic layer was washed with brine dried over anhydrous magnesium sulfate The solvent was removed under reduced pressure The residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate)

反応条件: temp:220.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a solution of 5-benzyloxy-6-methyl-1H-indole-2-carboxylic acid (0.6 g) in quinoline (6 mL) was added copper powder (0.15 g), and this mixture was stirred at 220° C. for 20 minutes. This reaction mixture was poured into 1 mol/L hydrochloric acid, the resulting mixture was extracted with ethyl acetate. This organic layer was washed with brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate) to give the title compound (0.21 g). the resulting mixture was extracted with ethyl acetate This organic layer was washed with brine dried over anhydrous magnesium sulfate The solvent was removed under reduced pressure The residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate)

反応条件: temp:220.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a solution of 5-benzyloxy-6-methyl-1H-indole-2-carboxylic acid (0.6 g) in quinoline (6 mL) was added copper powder (0.15 g), and this mixture was stirred at 220° C. for 20 minutes. This reaction mixture was poured into 1 mol/L hydrochloric acid, the resulting mixture was extracted with ethyl acetate. This organic layer was washed with brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate) to give the title compound (0.21 g). the resulting mixture was extracted with ethyl acetate This organic layer was washed with brine dried over anhydrous magnesium sulfate The solvent was removed under reduced pressure The residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate)

反応条件: temp:220.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a solution of 5-benzyloxy-6-methyl-1H-indole-2-carboxylic acid (0.6 g) in quinoline (6 mL) was added copper powder (0.15 g), and this mixture was stirred at 220° C. for 20 minutes. This reaction mixture was poured into 1 mol/L hydrochloric acid, the resulting mixture was extracted with ethyl acetate. This organic layer was washed with brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate) to give the title compound (0.21 g). the resulting mixture was extracted with ethyl acetate This organic layer was washed with brine dried over anhydrous magnesium sulfate The solvent was removed under reduced pressure The residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate)

反応条件: temp:220.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a solution of 5-benzyloxy-6-methyl-1H-indole-2-carboxylic acid (0.6 g) in quinoline (6 mL) was added copper powder (0.15 g), and this mixture was stirred at 220° C. for 20 minutes. This reaction mixture was poured into 1 mol/L hydrochloric acid, the resulting mixture was extracted with ethyl acetate. This organic layer was washed with brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate) to give the title compound (0.21 g). the resulting mixture was extracted with ethyl acetate This organic layer was washed with brine dried over anhydrous magnesium sulfate The solvent was removed under reduced pressure The residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate)