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CC(C)(C)OC(=O)NCC1=C(C=CC(=C1)Cl)O製品情報
tert-butyl N-[(5-chloro-2-hydroxyphenyl)methyl]carbamate (CAS 195517-88-5) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
想定用途
専門的研究・工業用途限定
データベース ID 11311441
安全上の注意
For professional research and industrial use only. Review the supplier safety data sheet before handling.
合成データ
12 反応 · 12 文献
反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-4608563ef0ed4d69a55075c94821e7a6反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of N-t-butoxycarbonyl-2-hydroxy-5-chloro-benzylamine (730 mg, 2.83 mmol), Cs2CO3 (923 mg, 2.83 mmol) and ethylbromoacetate (0.314 ml, 2.83 mmol) in DMF (5 ml) was stirred for 2 h. The crude reaction mixture was partitioned between ethyl acetate and water and the organic layer was washed with brine, dried (Na2SO4) and evaporated in vacuo to an oil which was used for the next step. The crude reaction mixture was partitioned between ethyl acetate and water the organic layer was washed with brine dried (Na2SO4) evaporated in vacuo to an oil which
ソース ID: ord-b03b1025afdf460a9042e23223557a4c反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 2-hydroxy-5-chlorobenzylamine (1.22 g, 4.77 mmol assuming the bisulfate salt), (BOC)2O (1.56 g, 7.16 mmol) and N-methylmorpholine (1.05 ml, 9.54 mmol) in DMF (10 ml) was stirred for 5 h at r.t. The reaction was partitioned between water and ethyl acetate and the organic layer was washed with 5% KHSO4 solution (2 times), sodium hydrogen carbonate solution and brine, dried (Na2SO4) and evaporated in vacuo to a solid. The crude product was recrystallized from ethyl acetate/hexanes (1:5, 12 ml) to give the title compound: The reaction was partitioned between water and ethyl acetate the organic layer was washed with 5% KHSO4 solution (2 times), sodium hydrogen carbonate solution and brine dried (Na2SO4) evaporated in vacuo to a solid The crude product was recrystallized from ethyl acetate/hexanes (1:5, 12 ml)
ソース ID: ord-e96e2b07aa7f44d18e061ff6a4f9d04f反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of N-t-butoxycarbonyl-2-hydroxy-5-chlorobenzylamine (730 mg, 2.83 mmol), Cs2CO3 (923 mg, 2.83 mmol) and ethylbromoacetate (0.314 ml, 2.83 mmol) in DMF (5 ml) was stirred for 2 h. The crude reaction mixture was partitioned between ethyl acetate and water and the organic layer was washed with brine, dried (Na2SO4) and evaporated in vacuo to an oil which was used for the next step. The crude reaction mixture was partitioned between ethyl acetate and water the organic layer was washed with brine dried (Na2SO4) evaporated in vacuo to an oil which
ソース ID: ord-b95815e639a24d64816a643ab534f762反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of N-t-butoxycarbonyl-2-hydroxy-5-chlorobenzylamine (730 mg, 2.83 mmol), Cs2CO3 (923 mg, 2.83 mmol) and ethylbromoacetate (0.314 ml, 2.83 mmol) in DMF (5 ml) was stirred for 2 h. The crude reaction mixture was partitioned between ethyl acetate and water and the organic layer was washed with brine, dried (Na2SO4) and evaporated in vacuo to an oil which was used for the next step. The crude reaction mixture was partitioned between ethyl acetate and water the organic layer was washed with brine dried (Na2SO4) evaporated in vacuo to an oil which
ソース ID: ord-b95815e639a24d64816a643ab534f762反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 2-hydroxy-5-chlorobenzylamine (1.22 g, 4.77 mmol assuming the bisulfate salt), (BOC)2O (1.56 g, 7.16 mmol) and N-methylmorpholine (1.05 ml, 9.54 mmol) in DMF (10 ml) was stirred for 5 h at r.t. The reaction was partitioned between water and ethyl acetate and the organic layer was washed with 5% KHSO4 solution (2 times), sodium hydrogen carbonate solution and brine, dried (Na2SO4) and evaporated in vacuo to a solid. The crude product was recrystallized from ethyl acetate/hexanes (1:5, 12 ml) to give the title compound: The reaction was partitioned between water and ethyl acetate the organic layer was washed with 5% KHSO4 solution (2 times), sodium hydrogen carbonate solution and brine dried (Na2SO4) evaporated in vacuo to a solid The crude product was recrystallized from ethyl acetate/hexanes (1:5, 12 ml)
ソース ID: ord-cc51bd14ae5b44c990124325d7020742反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of N-t-butoxycarbonyl-2-hydroxy-5-chlorobenzylamine (730 mg, 2.83 mmol), Cs2CO3 (923 mg, 2.83 mmol) and ethylbromoacetate (0.314 ml, 2.83 mmol) on DMF (5 ml) was stirred for 2 h. The crude reaction mixture was partitioned between ethyl acetate and water and the organic layer was washed with brine, dried (Na2SO4) and evaporated in vacuo to an oil which was used for the next step. The crude reaction mixture was partitioned between ethyl acetate and water the organic layer was washed with brine dried (Na2SO4) evaporated in vacuo to an oil which
ソース ID: ord-7d216abf88ae44748a4dfdfa38346d78反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 2-hydroxy-5-chlorobenzylamine (1.22 g, 4.77 mmol assuming the bisulfate salt), (BOC)2O (1.56 g, 7.16 mmol) and N-methylmorpholine (1.05 ml, 9.54 mmol) in DMF (10 ml) was stirred for 5 h at r.t. The reaction was partitioned between water and ethyl acetate and the organic layer was washed with 5% KHSO4 solution (2 times), sodium hydrogen carbonate solution and brine, dried (Na2SO4) and evaporated in vacuo to a solid. The crude product was recrystallized from ethyl acetate/hexanes (1:5, 12 ml) to give the title compound: The reaction was partitioned between water and ethyl acetate the organic layer was washed with 5% KHSO4 solution (2 times), sodium hydrogen carbonate solution and brine dried (Na2SO4) evaporated in vacuo to a solid The crude product was recrystallized from ethyl acetate/hexanes (1:5, 12 ml)
ソース ID: ord-3abf86d272794b9ba786beb23e85acdd反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of N-t-butoxycarbonyl-2-hydroxy-5-chloro-benzylamine (730 mg, 2.83 mmol), Cs2CO3 (923 mg, 2.83 mmol) and ethylbromoacetate (0.314 ml, 2.83 mmol) in DMF (5 ml) was stirred for 2 h. The crude reaction mixture was partitioned between ethyl acetate and water and the organic layer was washed with brine, dried (Na2SO4) and evaporated in vacuo to an oil which was used for the next step. The crude reaction mixture was partitioned between ethyl acetate and water the organic layer was washed with brine dried (Na2SO4) evaporated in vacuo to an oil which
ソース ID: ord-b03b1025afdf460a9042e23223557a4c反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of N-t-butoxycarbonyl-2-hydroxy-5-chloro-benzylamine (730 mg, 2.83 mmol), Cs2CO3 (923 mg, 2.83 mmol) and ethylbromoacetate (0.314 ml, 2.83 mmol) in DMF (5 ml) was stirred for 2 h. The crude reaction mixture was partitioned between ethyl acetate and water and the organic layer was washed with brine, dried (Na2SO4) and evaporated in vacuo to an oil which was used for the next step. The crude reaction mixture was partitioned between ethyl acetate and water the organic layer was washed with brine dried (Na2SO4) evaporated in vacuo to an oil which
ソース ID: ord-b03b1025afdf460a9042e23223557a4c反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 2-hydroxy-5-chlorobenzylamine (1.22 g, 4.77 mmol assuming the bisulfate salt), (BOC)2O (1.56 g, 7.16 mmol) and N-methylmorpholine (1.05 ml, 9.54 mmol) in DMF (10 ml) was stirred for 5 h at r.t. The reaction was partitioned between water and ethyl acetate and the organic layer was washed with 5% KHSO4 solution (2 times), sodium hydrogen carbonate solution and brine, dried (Na2SO4) and evaporated in vacuo to a solid. The crude product was recrystallized from ethyl acetate/hexanes (1:5, 12 ml) to give the title compound: The reaction was partitioned between water and ethyl acetate the organic layer was washed with 5% KHSO4 solution (2 times), sodium hydrogen carbonate solution and brine dried (Na2SO4) evaporated in vacuo to a solid The crude product was recrystallized from ethyl acetate/hexanes (1:5, 12 ml)
ソース ID: ord-e96e2b07aa7f44d18e061ff6a4f9d04f反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-4608563ef0ed4d69a55075c94821e7a6PubChem References
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