1-(3-phenylpropyl)piperazin-2-one

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Concentrated hydrochloric acid (4.2 ml) was added to 4-tert-butoxycarbonyl-1-(3-phenylpropan-1-yl)-2-oxopiperazine (3.85 g, 12.1 mmol) at room temperature and the mixture was stirred at room temperature for 1 hour. The reaction mixture was basified with 8N-sodium hydroxide and extracted with ethyl acetate. The extract was washed with brine, dried over MgSO4 and concentrated in vacuo to give 1-(3-phenylpropan-1-yl)-2-oxopiperazine as a colorless oil (2.49 g, 94%). extracted with ethyl acetate The extract was washed with brine dried over MgSO4 concentrated in vacuo