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CCOC(COC1=CC(=CC=C1)Br)OCC製品情報
1-bromo-3-(2,2-diethoxyethoxy)benzene (CAS 204452-94-8) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
想定用途
専門的研究・工業用途限定
データベース ID 15453765
安全上の注意
For professional research and industrial use only. Review the supplier safety data sheet before handling.
合成データ
12 反応 · 12 文献
反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-aaf5e6bad2204705b298c89a8803ecd2反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-59d32a24a61f44a18bcba02d66953cb4反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-844933fc505343f7a37fc6801de89fd3反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-8363cfd08c23491ea01cd9d0ba6a25b7反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a solution of the acetal 6-2 in toluene (200 mL) was added polyphosphoric acid (20 g). The biphasic mixture was heated to 100° C. and stirred at this temperature for 4 h. The mixture was cooled to room temperature, poured onto ice, and extracted with Et2O (2×200 mL). The combined organic extracts were washed with saturated aq. NaHCO3 and brine. The solution was dried over MgSO4, filtered, and concentrated. The residue was purified by flash chromatography (100% hexanes) to give the product 6-3 as a yellow oil. The mixture was cooled to room temperature poured onto ice extracted with Et2O (2×200 mL) The combined organic extracts were washed with saturated aq. NaHCO3 and brine The solution was dried over MgSO4 filtered concentrated The residue was purified by flash chromatography (100% hexanes)
ソース ID: ord-4226edea835c42a8bd810cad13e530ea反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a suspension of NaH (2.77 g, 115.6 mmol) in DMF (100 mL) at 0° C. was added a solution of 3-bromophenol 6-1 in DMF (40 mL) over 40 min. After the addition was complete, the solution was stirred for an additional 30 min. The solution was then treated with neat bromoacetaldehyde diethyl acetal (17.36 g, 115.6 mmol). The solution was heated at 100° C. for 8 h, cooled to room temperature, and extracted with Et2O (3×200 mL). The combined organic extracts were washed with 10% aq. NaOH (100 mL) and brine (100 mL), dried over MgSO4, filtered and concentrated to give 6-2 as a yellow oil. After the addition cooled to room temperature extracted with Et2O (3×200 mL) The combined organic extracts were washed with 10% aq. NaOH (100 mL) and brine (100 mL) dried over MgSO4 filtered concentrated
ソース ID: ord-eebc49c6774b4b758fa04e755bd90293反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a solution of the acetal 15-2 in toluene (200 mL) was added polyphosphoric acid (20 g). The biphasic mixture was heated to 100° C. and stirred at this temperature for 4 h. The mixture was cooled to room temperature, poured onto ice, and extracted with Et2O (2×200 mL). The combined organic extracts were washed with saturated aq NaHCO3 and brine. The solution was dried over MgSO4, filtered, and concentrated. The residue was purified by flash chromatography (100% hexanes) to give the product 15-3 as a yellow oil. The mixture was cooled to room temperature poured onto ice extracted with Et2O (2×200 mL) The combined organic extracts were washed with saturated aq NaHCO3 and brine The solution was dried over MgSO4 filtered concentrated The residue was purified by flash chromatography (100% hexanes)
ソース ID: ord-d91a457291414103a95ad2230eeac512反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a suspension of NaH (2.77 g, 115.6 mmol) in DMF (100 mL) at 0° C. was added a solution of 3-bromophenol 15-1 in DMF (40 mL) over 40 min. After the addition was complete, the solution was stirred for an additional 30 min. The solution was then treated with neat bromoacetaldehyde diethyl acetal (17.36 g, 115.6 mmol). The solution was heated at 100° C. for 8 h, cooled to room temperature, and extracted with Et2O (3×200 mL). The combined organic extracts were washed with 10% aq NaOH (100 mL) and brine (100 mL), dried over MgSO4, filtered and concentrated to give 15-2 as a yellow oil. After the addition cooled to room temperature extracted with Et2O (3×200 mL) The combined organic extracts were washed with 10% aq NaOH (100 mL) and brine (100 mL) dried over MgSO4 filtered concentrated
ソース ID: ord-6b3d4a734dca402ebd3bc334e8db2ec9反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a suspension of NaH (2.77 g, 115.6 mmol) in DMF (100 mL) at 0° C. was added a solution of 3-bromophenol 3-1 in DMF (40 mL) over 40 min. After the addition was complete, the solution was stirred for an additional 30 min. The solution was then treated with neat bromoacetaldehyde diethyl acetal (17.36 g, 115.6 mmol). The solution was heated at 100° C. for 8 h, cooled to room temperature, and extracted with Et2O (3×200 mL). The combined organic extracts were washed with 10% aq. NaOH (100 mL) and brine (100 mL), dried over MgSO4, filtered and concentrated to give 3-2 as a yellow oil. After the addition cooled to room temperature extracted with Et2O (3×200 mL) The combined organic extracts were washed with 10% aq. NaOH (100 mL) and brine (100 mL) dried over MgSO4 filtered concentrated
ソース ID: ord-4919b8cd65cc4b00ac88c0cbec3bfeb7反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-aaf5e6bad2204705b298c89a8803ecd2反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a solution of the acetal 3-2 in toluene (200 mL) was added polyphosphoric acid (20 g). The biphasic mixture was heated to 100° C. and stirred at this temperature for 4 h. The mixture was cooled to room temperature, poured onto ice, and extracted with Et2O (2×200 mL). The combined organic extracts were washed with saturated aq. NaHCO3 and brine. The solution was dried over MgSO4, filtered, and concentrated. The residue was purified by flash chromatography (100% hexanes) to give the product 3-3 as a yellow oil. The mixture was cooled to room temperature poured onto ice extracted with Et2O (2×200 mL) The combined organic extracts were washed with saturated aq. NaHCO3 and brine The solution was dried over MgSO4 filtered concentrated The residue was purified by flash chromatography (100% hexanes)
ソース ID: ord-9115098a55be470798ea43637728d10a反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a suspension of NaH (2.77 g, 115.6 mmol) in DMF (100 mL) at 0° C. was added a solution of 3-bromophenol 3-1 in DMF (40 mL) over 40 min. After the addition was complete, the solution was stirred for an additional 30 min. The solution was then treated with neat bromoacetaldehyde diethyl acetal (17.36 g, 115.6 mmol). The solution was heated at 100° C. for 8 h, cooled to room temperature, and extracted with Et2O (3×200 mL). The combined organic extracts were washed with 10% aq. NaOH (100 mL) and brine (100 mL), dried over MgSO4, filtered and concentrated to give 3-2 as a yellow oil. After the addition cooled to room temperature extracted with Et2O (3×200 mL) The combined organic extracts were washed with 10% aq. NaOH (100 mL) and brine (100 mL) dried over MgSO4 filtered concentrated
ソース ID: ord-ccd8d9c3e13f4401905866634dd2f8cfPubChem References
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